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galbonolide

National Institutes of Health

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rustmicin

Papers overview

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2015
2015
Heterologous expression of galbonolide biosynthetic genes in Streptomyces coelicolor
The galbonolide antibiotics are non-glycosylated heptaketide 14-membered macrolides. These antibiotics exhibit broad-spectrum… 
2014
2014
A Single Module Type I Polyketide Synthase Directs de Novo Macrolactone Biogenesis during Galbonolide Biosynthesis in Streptomyces galbus*
Background: Galbonolide (GAL) was proposed to be synthesized by a modular type I polyketide synthase (PKS) with GalA-E serving a… 
2010
2010
The methoxymalonyl-acyl carrier protein biosynthesis locus and the nearby gene with the beta-ketoacyl synthase domain are involved in the biosynthesis of galbonolides in Streptomyces galbus, but…
Galbonolides A and B are antifungal compounds, which are produced by Streptomyces galbus. A multimodular polyketide synthase (PKS… 
2007
2007
A total synthesis of galbonolide B.
An ester enolate rearrangement/silicon mediated fragmentation cascade was used to convert 7 and 8 into the alcohol 9. The alcohol… 
2004
2004
Synthesis and antifungal activity of novel 14-membered benzomacrolides, as galbonolide analogues.
Asymmetric total synthesis of benzene analogues of galbonolide, a 14-membered antifungal macrolide, possessing a benzene ring… 
2004
2004
Novel galbonolide derivatives as IPC synthase inhibitors: design, synthesis and in vitro antifungal activities.
2004
2004
Synthesis of a key intermediate of novel galbonolide analogues via efficient construction of a conjugated diene system.
The development of an efficient synthetic method enabled multi-gram synthesis of a key intermediate, which is useful for the… 
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