galbonolide
National Institutes of Health
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The galbonolide antibiotics are non-glycosylated heptaketide 14-membered macrolides. These antibiotics exhibit broad-spectrum…
Background: Galbonolide (GAL) was proposed to be synthesized by a modular type I polyketide synthase (PKS) with GalA-E serving a…
Galbonolides A and B are antifungal compounds, which are produced by Streptomyces galbus. A multimodular polyketide synthase (PKS…
An ester enolate rearrangement/silicon mediated fragmentation cascade was used to convert 7 and 8 into the alcohol 9. The alcohol…
Asymmetric total synthesis of benzene analogues of galbonolide, a 14-membered antifungal macrolide, possessing a benzene ring…
The development of an efficient synthetic method enabled multi-gram synthesis of a key intermediate, which is useful for the…