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fusion inhibitor

Known as: fusion inhibitors 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Kinetically coupled folding of a single HIV-1 glycoprotein 41 complex in viral membrane fusion and inhibition
Significance Enveloped viruses infect cells via fusion of viral and host cell membranes mediated by highly conserved fusion… 
2015
2015
Cholesterol conjugation potentiates the antiviral activity of an HIV immunoadhesin
Immunoadhesins are engineered proteins combining the constant domain (Fc) of an antibody with a ligand‐binding (adhesion) domain… 
2014
2014
Characterization of Gp41 Polymorphisms in the Fusion Peptide Domain and T-20 (Enfuvirtide) Resistance-Associated Regions in Korean HIV-1 Isolates
HIV-1 gp41 is an envelope protein that plays an essential role in virus entry. The mutation of gp41 affects HIV-1 entry and… 
2014
2014
The use of hairpin DNA duplexes as HIV-1 fusion inhibitors: synthesis, characterization, and activity evaluation.
2011
2011
Inhibition of HIV-1 Env-Mediated Cell-Cell Fusion by Lectins, Peptide T-20, and Neutralizing Antibodies
Background: Broadly cross-reactive, neutralizing human monoclonal antibodies, including 2F5, 2G12, 4E10 and IgG1 b12, can inhibit… 
2009
2009
CD4-anchoring HIV-1 Fusion Inhibitor with Enhanced Potency and in Vivo Stability*
In this study, we describe a novel CD4-targeting bifunctional human immunodeficiency virus (HIV-1) fusion inhibitor (CD4-BFFI… 
2007
2007
Evolution of genotypic and phenotypic resistance during chronic treatment with the fusion inhibitor T-1249.
T-1249 is a peptide HIV fusion inhibitor (FI) previously under development for use in FI-naive and experienced patients. Here we… 
Review
2006
Review
2006
New antiretroviral drugs in clinical use
The advent of combination antiretroviral therapy for the treatment of human immunodeficiency virus (HIV) infection has… 
Review
2005
Review
2005
Pharmacokinetics of Antiretroviral Therapy in HIV-1-Infected Children
The initiation of antiretroviral therapy has resulted in an impressive reduction in the rate of disease progression in AIDS and… 
2004
2004
Resistance and replicative capacity of HIV-1 strains selected in vivo by long-term enfuvirtide treatment.
Enfuvirtide is the prototype member of a new class of anti HIV-1 agents, the fusion inhibitors (FI). In recent clinical trials… 
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