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fluspidine

National Institutes of Health

Papers overview

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2019
2019
Short and atom economic enantioselective synthesis of the σ1 receptor ligands (S)- and (R)-fluspidine - important tools for PET studies.
Aryl bromides 2a and 2b bearing an alkynyl substituent in o-position reacted with n-butyllithium and 1-benzylpiperidin-4-one in a… 
2018
2018
Assessment of sigma-1 receptor occupancy in mice with non-radiolabelled FTC-146 as a tracer
Abstract The use of liquid chromatography coupled with mass spectrometry (LC-MS/MS) is advantageous in in-vivo receptor occupancy… 
Review
2017
Review
2017
Fluorinated PET Tracers for Molecular Imaging of σ1 Receptors in the Central Nervous System.
At first the role of σ1 receptors in various neurological, psychiatric and neurodegenerative disorders is discussed. In the… 
2013
2013
Synthesis, Characterization, and Metabolism Studies of Fluspidine Enantiomers
The enantiomers of the potent σ1 ligand fluspidine (1) were prepared by using chiral preparative HPLC. Synthesis of racemic… 
2011
2011
Synthesis, pharmacological activity and structure affinity relationships of spirocyclic σ(1) receptor ligands with a (2-fluoroethyl) residue in 3-position.
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