flippase
National Institutes of Health
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Flipping a lipid The membranes of eukaryotic cells have different lipid compositions in their inner and outer leaflets. Enzymes…
The heterodimeric eukaryotic Drs2p-Cdc50p complex is a lipid flippase that maintains cell membrane asymmetry. The enzyme complex…
Ever since daptomycin was introduced to the clinic, daptomycin-resistant isolates have been reported. In most cases, the…
ABSTRACT Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal meningitis in immunocompromised…
The biosynthesis of cellular polysaccharides and glycoconjugates often involves lipid-linked intermediates that need to be…
Viable cancer cells expose elevated levels of phosphatidylserine (PS) on the exoplasmic face of the plasma membrane. However, the…
In plasma membranes, flippases translocate aminophospholipids such as phosphatidylserine and phosphatidylethanolamine from the…
Lipid asymmetry at the plasma membrane is essential for such processes as cell polarity, cytokinesis and phagocytosis. Here we…
The MsbA protein is an essential ABC (ATP-binding-cassette) superfamily member in Gram-negative bacteria. This 65 kDa membrane…
Transbilayer movement of phospholipids in biological membranes is mediated by energy-dependent and energy-independent flippases…