FAQ

flap endonuclease activity

Catalysis of the cleavage of a flap structure in DNA, but not other DNA structures; processes the ends of Okazaki fragments in lagging strand DNA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2017
012319962017

Papers overview

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2014
2014
Catalytic and noncatalytic roles of the CtIP endonuclease in double-strand break end resection.
The carboxy-terminal binding protein (CtBP)-interacting protein (CtIP) is known to function in 5' strand resection during… (More)
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2014
2014
Flap endonuclease activity of gene 6 exonuclease of bacteriophage T7.
Flap endonucleases remove flap structures generated during DNA replication. Gene 6 protein of bacteriophage T7 is a 5'-3… (More)
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Highly Cited
2009
Highly Cited
2009
Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases
Structure-specific endonucleases resolve DNA secondary structures generated during DNA repair and recombination. The yeast 5… (More)
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2007
2007
DmGEN shows a flap endonuclease activity, cleaving the blocked-flap structure and model replication fork.
Drosophila melanogaster XPG-like endonuclease (DmGEN) is a new category of nuclease belonging to the RAD2/XPG family. The DmGEN… (More)
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2002
2002
Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination.
Flap endonuclease-1 (FEN-1) is a critical enzyme for DNA replication and repair. Intensive studies have been carried out on its… (More)
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2001
2001
Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage.
In eukaryotes, the nuclease activity of Rad27p (Fen1p) is thought to play a critical role in lagging-strand DNA replication by… (More)
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Highly Cited
1999
Highly Cited
1999
The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activities.
The RAD2 family of nucleases includes human XPG (Class I), FEN1 (Class II), and HEX1/hEXO1 (Class III) products gene. These… (More)
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1999
1999
The RAG1/RAG2 complex constitutes a 3' flap endonuclease: implications for junctional diversity in V(D)J and transpositional recombination.
During V(D)J recombination, processing of branched coding end intermediates is essential for generating junctional diversity… (More)
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1997
1997
Functional analysis of point mutations in human flap endonuclease-1 active site.
Human flap endonuclease-1 (hFEN-1) is highly homologous to human XPG, Saccharomyces cerevisiae RAD2 and S.cerevisiae RTH1 and… (More)
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1997
1997
The 5'-exonuclease activity of bacteriophage T4 RNase H is stimulated by the T4 gene 32 single-stranded DNA-binding protein, but its flap endonuclease is inhibited.
Bacteriophage T4 RNase H is a 5'- to 3'-nuclease that has exonuclease activity on RNA.DNA and DNA.DNA duplexes and can remove the… (More)
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