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fibroblast activation

A change in the morphology or behavior of a fibroblast resulting from exposure to an activating factor such as a cellular or soluble ligand. [CL… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Whole Exome Sequencing Reveals a Novel Damaging Mutation in Human Fibroblast Activation Protein in a Family with Esophageal Squamous Cell Carcinoma
Purpose Esophageal squamous cancer cell (ESCC), with late diagnosis and poor rate of survival, is a significant cause of… 
2018
2018
Downregulation of SPIN90 promotes fibroblast activation via periostin‐FAK‐ROCK signaling module
Alterations in mechanical properties in the extracellular matrix are modulated by myofibroblasts and are required for progressive… 
2017
2017
Structure‐based derivation of peptide inhibitors to target TGF‐β1 receptor for the suppression of hypertrophic scarring fibroblast activation
The intermolecular recognition and interaction between human transforming growth factor β‐1 (TGF‐β1) and its cognate receptor T… 
Review
2017
Review
2017
Potential disease biomarkers: dipeptidyl peptidase 4 and fibroblast activation protein
The importance of the dipeptidyl peptidase 4 (DPP4) gene family in regulating critical biochemical pathways continues to emerge… 
2017
2017
High expression of fibroblast activation protein is an adverse prognosticator in gastric cancer
Background: Human Fibroblast Activation Protein (FAP) is a surface glycoprotein expressed on cancer associated fibroblasts in the… 
2016
2016
MAD2B-mediated SnoN downregulation is implicated in fibroblast activation and tubulointerstitial fibrosis.
MAD2B, an anaphase-promoting complex/cyclosome (APC/C) inhibitor and a small subunit of DNA polymerase ζ, is indispensible for… 
2013
2013
P190B RhoGAP Overexpression in the Developing Mammary Epithelium Induces TGFβ-dependent Fibroblast Activation
Rho GTPases mediate stromal-epithelial interactions that are important for mammary epithelial cell (MEC) morphogenesis. Increased… 
2010
2010
Bacillus Calmette Guerin Induces Fibroblast Activation Both Directly and through Macrophages in a Mouse Bladder Cancer Model
Background Bacillus Calmette-Guerin (BCG) is the most effective treatment for non-muscle invasive bladder cancer. However, a… 
Review
2010
Review
2010
Andrew Leask CCN 2 , and PDGF , Partners in Fibroblast Activation , Angiotensin , Endothelin , β Potential Therapeutic Targets for Cardiac Fibrosis : TGF
Fibrosis is one of the largest groups of diseases for which there is no therapy but is believed to occur because of a persistent… 
2007
2007
Inhibitors of Fibroblast Activation Protein (FAP) Inhibit Primary Myeloma Growth and Osteoclastogenesis Ex Vivo and In Vivo.
Fibroblast activation protein (FAP), a cell surface serine protease with both dipeptidyl peptidase and collagenase activity, is… 
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