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ferroquine

National Institutes of Health

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AminoquinolinesFerrous Compounds

Papers overview

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2019
2019
In vitro activity of ferroquine against artemisinin-based combination therapy (ACT)-resistant Plasmodium falciparum isolates from Cambodia.
BACKGROUND Cambodia is the epicentre of resistance emergence for virtually all antimalarial drugs. Selection and spread of… 
2017
2017
Phase 2a, Open-Label, 4-Escalating-Dose, Randomized Multicenter Study Evaluating the Safety and Activity of Ferroquine (SSR97193) Plus Artesunate, versus Amodiaquine Plus Artesunate, in African Adult…
Artemisinin-based combination therapies are recommended as first-line agents for treating uncomplicated Plasmodium falciparum… 
2013
2013
The antimalarial ferroquine is an inhibitor of hepatitis C virus†, ‡
Hepatitis C virus (HCV) is a major cause of chronic liver disease. Despite recent success in improving anti‐HCV therapy… 
Highly Cited
2012
Highly Cited
2012
Pharmacokinetics of Ferroquine, a Novel 4-Aminoquinoline, in Asymptomatic Carriers of Plasmodium falciparum Infections
ABSTRACT Ferroquine (SSR97193), a ferrocene-quinoline conjugate, is a promising novel antimalarial currently undergoing clinical… 
Highly Cited
2011
Highly Cited
2011
Phase I randomized dose-ascending placebo-controlled trials of ferroquine - a candidate anti-malarial drug - in adults with asymptomatic Plasmodium falciparum infection
BackgroundThe development and spread of drug resistant Plasmodium falciparum strains is a major concern and novel anti-malarial… 
2011
2011
Inhibitory activity of ferroquine, versus chloroquine, against western Kenya Plasmodium falciparum field isolates determined by a SYBR Green I in vitro assay.
Ferroquine (FQ), a chloroquine (CQ) analog, is being developed to treat persons with Plasmodium falciparum malaria. In 146 P… 
2010
2010
Plasmodium vivax Susceptibility to Ferroquine
ABSTRACT The novel organometallic chloroquine analog ferroquine (SSR 97193) is effective against chloroquine-resistant… 
2010
2010
Ferroquina: O Antimalárico do Futuro
A malaria e uma doenca parasitaria que aflige aproximadamente 500 milhoes de pessoas e causa mais de um milhao de mortes por ano… 
2006
2006
IN VITRO METABOLISM OF FERROQUINE (SSR97193) IN ANIMAL AND HUMAN HEPATIC MODELS AND ANTIMALARIAL ACTIVITY OF MAJOR METABOLITES ON PLASMODIUM FALCIPARUM
Ferroquine (SSR97193) has been shown to be a promising antimalarial, both on laboratory clones and on field isolates. So far, no… 
Highly Cited
2002
Highly Cited
2002
Synthesis of Ferroquine Enantiomers: First Investigation of Effects of Metallocenic Chirality upon Antimalarial Activity and Cytotoxicity
Ferroquine (FQ) is a new antimalarial agent with a high blood schizotoncidal activity. Previous studies on this compound were… 
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