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evofosfamide

 
National Institutes of Health

Papers overview

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2018
2018
Abstract Aims: Evofosfamide (TH-302) is a hypoxia-activated prodrug (HAP) that releases the DNA-damaging bromo-isophosphoramide… Expand
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2017
2017
This study was designed to investigate the effect of single-dose radiation therapy (RT) in combination with evofosfamide (TH-302… Expand
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2016
2016
4007Background: Hypoxia in PDAC is associated with disease progression and poor prognosis. Evo is a hypoxia-activated prodrug of… Expand
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2016
2016
193 Background: Pancreatic ductal adenocarcinoma (PDAC) is invariably diagnosed at an advanced stage and has poor clinical… Expand
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2016
2016
PURPOSE Tumor cells residing in tumor hypoxic zones are a major cause of drug resistance and tumor relapse. In this study, we… Expand
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2016
2016
High-grade gliomas are often characterized by hypoxia, which is associated with both poor long-term prognosis and therapy… Expand
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Review
2016
Review
2016
It is well established that hypoxia is prevalent in human tumors and is associated with resistance to radiotherapy and… Expand
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2016
2016
Tumor hypoxia is a major cause of treatment failure for a variety of malignancies. However, hypoxia offers treatment… Expand
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2016
2016
Tumor hypoxia causes resistance to radiation and chemotherapy. Evofosfamide (TH-302) has exhibited specific hypoxia-dependent… Expand
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2015
2015
Tumors often consist of hypoxic regions which are resistant to chemo- and radiotherapy. Evofosfamide (also known as TH-302), a 2… Expand
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