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etozolin

Known as: Etozoline, ethyl (3-methyl-4-oxo-5-piperidinothiazolidin-2-ylidene)acetate 
A long-acting loop diuretic. Etozolin appears to be rapidly metabolized to its active metabolite ozolinone.
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Antihypertensive AgentsDiureticsThiazoles

Narrower (1)

Elkapin

Papers overview

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2004
2004
Pharmacodynamics and kinetics of etozolin/ozolinone in hypertensive patients with normal and impaired kidney function
SummaryThe effect on urinary electrolyte excretion, renin release and plasma norepinephrine of single oral doses of 400 mg… 
1991
1991
Diuretic therapy for mild hypertension : a comparison of the metabolic effects of etozoline and chlorthalidone during long-term treatment
1987
1987
Experimental study with D-ozolinone and L-ozolinone metabolites of etozoline
1980
1980
Independent of etozolin elimination of kidney function. Single dose experiments in patients with renal insufficiency.
Following a single oral dose of the novel diuretic ethyl (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene) acetate… 
1980
1980
Assay of etozolin and its main metabolite, ozolinone, in plasma by high performance liquid chromatography.
A sensitive and specific method for the determination of the diuretic Ethyl (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2… 
1979
1979
[Studies on the diuretic effects of etozolin (Elkapin) in heart failure - a comparison with the loop diuretic agent furosemide (author's transl)].
UNLABELLED In 115 randomized patients with left and/or right ventricular failure, the effect of the new diuretic Etozolin (800 mg… 
1978
1978
[The anti-hypertensive effect of the diuretic etozolin. Results of a double-blind test].
In a double-blind study under strict, standardized hospital conditions, the antihypertensive effect of etozolin was evalulated in… 
1977
1977
Effect of Etozolin on whole kidney function and fluid and electrolyte reabsorption in rat proximal convoluted tubules and loops of Henle.
The effects of ethyl (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene) acetate (etozolin, Elkapin) on whole kidney function… 
1977
1977
[Toxicological studies on Etozolin (author's transl)].
The tolerance of ethyl (Z)-(3-methyl-4-oxo-5-piperidino-thiazolidin-2-ylidene)acetate (etozolin, Gö 687, Elkapin) has been… 
1977
1977
[Structure-activity relationships of etozolin, a novel diuretic (author's transl)].
Selection of a structurally confined group of diuretics out of 2-methylenethiazolidones-(4), a new class of compounds, and… 
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