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establishment of epithelial cell polarity

The specification and formation of anisotropic intracellular organization of an epithelial cell. [GOC:ascb_2009, GOC:dph, GOC:tb]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1988-2017
01219882017

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2014
2014
Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer.
Scribble (SCRIB) localizes to cell-cell junctions and regulates establishment of epithelial cell polarity. Loss of expression of… (More)
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2009
2009
Increased IP3/Ca2+ signaling compensates depletion of LET-413/DLG-1 in C. elegans epithelial junction assembly.
The let-413/scribble and dlg-1/discs large genes are key regulators of epithelial cell polarity in C. elegans and other systems… (More)
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Highly Cited
2008
Highly Cited
2008
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms.
LKB1 is a key regulator of energy homeostasis through the activation of AMP-activated protein kinase (AMPK) and is functionally… (More)
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2007
2007
The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation.
Three groups of evolutionarily conserved proteins have been implicated in the establishment of epithelial cell polarity: the… (More)
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Highly Cited
2004
Highly Cited
2004
Adherens junction-dependent and -independent steps in the establishment of epithelial cell polarity in Drosophila
Adherens junctions (AJs) are thought to be key landmarks for establishing epithelial cell polarity, but the origin of epithelial… (More)
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Highly Cited
2002
Highly Cited
2002
aPKC kinase activity is required for the asymmetric differentiation of the premature junctional complex during epithelial cell polarization.
We have previously shown that aPKC interacts with cell polarity proteins PAR-3 and PAR-6 and plays an indispensable role in cell… (More)
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Highly Cited
2002
Highly Cited
2002
Mammalian homolog of Drosophila tumor suppressor lethal (2) giant larvae interacts with basolateral exocytic machinery in Madin-Darby canine kidney cells.
The Drosophila tumor suppressor protein lethal (2) giant larvae [l(2)gl] is involved in the establishment of epithelial cell… (More)
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Highly Cited
1999
Highly Cited
1999
Differential behavior of E-cadherin and occludin in their colocalization with ZO-1 during the establishment of epithelial cell polarity.
At the initial stage of cell-cell contact of epithelial cells, primordial spot-like junctions are formed at the tips of thin… (More)
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1990
1990
Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules
It has been previously shown that A-chain and domain(E8)-specific antibodies to laminin that inhibit cell adhesion also interfere… (More)
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1988
1988
Exocytosis of vacuolar apical compartment (VAC): a cell-cell contact controlled mechanism for the establishment of the apical plasma membrane domain in epithelial cells
The vacuolar apical compartment (VAC) is an organelle found in Madin-Darby canine kidney (MDCK) cells with incomplete… (More)
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