FAQ

endocardial cushion development

The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2017
012319762017

Related topics

Related topics

3 relations

Narrower (2)

endocardial cushion cell differentiationendocardial cushion morphogenesis

Broader (1)

heart development

Related mentions per year

Related mentions per year

1954-2018
1960198020002020
endocardial cushion development
heart development
endocardial cushion morphogenesis
endocardial cushion cell differentiation

Papers overview

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2013
2013
Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis.
Cardiac valves are essential to direct forward blood flow through the cardiac chambers efficiently. Congenital valvular defects… (More)
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2011
2011
Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development.
Cardiac valves originate from endocardial cushions (EC) formed by endothelial-to-mesenchymal transformation (EMT) during… (More)
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2011
2011
Transmembrane protein 2 (Tmem2) is required to regionally restrict atrioventricular canal boundary and endocardial cushion development.
The atrioventricular canal (AVC) physically separates the atrial and ventricular chambers of the heart and plays a crucial role… (More)
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Highly Cited
2009
Highly Cited
2009
Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development.
Notch signaling is vital for proper cardiovascular development and function in both humans and animal models. Indeed, mutations… (More)
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2008
2008
Twist1 function in endocardial cushion cell proliferation, migration, and differentiation during heart valve development.
Twist1 is a bHLH transcription factor that regulates cell proliferation, migration, and differentiation in embryonic progenitor… (More)
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2008
2008
BMP4 is required in the anterior heart field and its derivatives for endocardial cushion remodeling, outflow tract septation, and semilunar valve development.
The endocardial cushions play a critical role in septation of the four-chambered mammalian heart and in the formation of the… (More)
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Highly Cited
2005
Highly Cited
2005
Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development.
Defects in cardiac valve morphogenesis and septation of the heart chambers constitute some of the most common human congenital… (More)
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2003
2003
Molecular markers of cardiac endocardial cushion development.
Endocardial cushions are precursors of mature heart valves. They form within the looped heart tube as discrete swellings and… (More)
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Highly Cited
2002
Highly Cited
2002
Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis.
The formation of endocardial cushions in the atrioventricular (AV) canal of the rudimentary heart requires epithelial-to… (More)
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1996
1996
Morphogenetic alterations during endocardial cushion development in the trisomy 16 (Down syndrome) mouse
Atrioventricular septal defect occurs with a high prevalence in both human Down syndrome (trisomy 21) and the animal model for… (More)
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