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endocardial cushion development

The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region… Expand
National Institutes of Health

Related topics

Related topics

3 relations

Narrower (2)

endocardial cushion cell differentiationendocardial cushion morphogenesis

Broader (1)

heart development

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development.
Cardiac valves originate from endocardial cushions (EC) formed by endothelial-to-mesenchymal transformation (EMT) during… Expand
Highly Cited
2011
Highly Cited
2011
Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development
We report that the dominant human missense mutations G303E and G296S in GATA4, a cardiac-specific transcription factor gene… Expand
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2009
2009
Muscleblind‐like 1 is a negative regulator of TGF‐β‐dependent epithelial–mesenchymal transition of atrioventricular canal endocardial cells
The development of the valves and septa of the heart depends on the formation and remodeling of endocardial cushions. Here, we… Expand
2007
2007
FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart.
Development of the heart valves is a complex process that relies on the successful remodeling of endocardial cushions. This… Expand
2006
2006
Morphogenetic alterations during endocardial cushion development in the trisomy 16 (Down syndrome) mouse
Atrioventricular septal defect occurs with a high prevalence in both human Down syndrome (trisomy 21) and the animal model for… Expand
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2004
2004
Rho-associated kinases play a role in endocardial cell differentiation and migration.
Development of the endocardial cushions in the heart involves cell migration and cell differentiation, which is known as… Expand
Highly Cited
2003
Highly Cited
2003
Molecular markers of cardiac endocardial cushion development
Endocardial cushions are precursors of mature heart valves. They form within the looped heart tube as discrete swellings and… Expand
Highly Cited
2003
Highly Cited
2003
Cardiac T-box factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart.
Tbx20 is a member of the T-box transcription factor family expressed in the forming hearts of vertebrate and invertebrate embryos… Expand
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Highly Cited
2002
Highly Cited
2002
Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis.
The formation of endocardial cushions in the atrioventricular (AV) canal of the rudimentary heart requires epithelial-to… Expand
Highly Cited
1981
Highly Cited
1981
Effects of vitamin A on endocardial cushion development in the mouse heart.
Retinoic acid (RA) (78mg/kg) administered to ICR mice on days 9.0,9.5 and 10.0 of pregnancy (plug day = day 1), resulted in… Expand
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