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eleutherobin

National Institutes of Health

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Diterpenes

Papers overview

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2018
2018
Synthesis of eunicellane-type bicycles embedding a 1,3-cyclohexadiene moiety
The first synthesis of diterpenoid eunicellane skeletons incorporating a 1,3-cyclohexadiene moiety is presented. Key step is a… 
Highly Cited
2016
Highly Cited
2016
Study of the Role of Anti-Cancer Molecules with Different Sizes for Decreasing Corresponding Bulk Tumor Multiple Organs or Tissues
The intermolecular forces between anti–cancer molecules such as Cisplatin, Carboplatin, Oxaliplatin, Nedaplatin, Lobaplation… 
2005
2005
Synthesis of a simplified analogue of eleutherobin via a Claisen rearrangement and ring closing metathesis strategy.
The enantioselective synthesis of a simplified eleutherobin analogue by ring closing metathesis (RCM) of the 2,9-divinyl… 
2005
2005
Efficient metathesis route to the B-ring of eleutherobin and other medium-sized cyclic ethers
2003
2003
A ring-closing metathesis approach to a synthesis of the B ring of eleutherobin
2002
2002
Total Synthesis of Eleutherobin and Analogs and Study of Anti-Cancer Mechanism
Abstract : The first total syntheses of protesome inhibitors TMC-95A & B have been achieved. Highlights of the synthesis include… 
2001
2001
Synthetic transformations of eleutherobin reveal new features of its microtubule-stabilizing pharmacophore.
Departments of Chemistry and EOSUniVersity of British ColumbiaVancouVer, British Columbia, Canada, V6T 1Z1Department of… 
Highly Cited
2000
Highly Cited
2000
Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts.
We describe a cell-based assay for antimitotic compounds that is suitable for drug discovery and for quantitative determination… 
2000
2000
Tubulin as a target for anticancer drugs.
Nature provides a large spectrum of agents that either inhibit the polymerization of tubulin or prevent the disassembly of… 
1995
1995
Eleutherobin and analogs thereof
Ai garnet Selo hormone (eleutherobin) is a structural formula (I) are glycosylated diterpene toxic to cancer cells is a cytotoxic… 
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