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elatol

National Institutes of Health

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Spiro Compounds

Papers overview

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2018
2018
Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity
Purpose: The DEAD-box RNA helicase eIF4A1 carries out the key enzymatic step of cap-dependent translation initiation and is a… Expand
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Review
2017
Review
2017
Marine Algae as Source of Novel Antileishmanial Drugs: A Review
Leishmaniasis is a vector-borne neglected tropical disease caused by protozoan parasites of the Leishmania genus and transmitted… Expand
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Highly Cited
2012
Highly Cited
2012
Anti‐tumour effects of elatol, a marine derivative compound obtained from red algae Laurencia microcladia
Objectives  This paper aims to evaluate the anti‐tumour properties of elatol, a compound (sesquiterpene) isolated from algae… Expand
2012
2012
Trypanocidal Action of (−)-Elatol Involves an Oxidative Stress Triggered by Mitochondria Dysfunction
Natural compounds have shown good potential for the discovery of new chemotherapeutics for the treatment of Chagas’ disease… Expand
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Highly Cited
2010
Highly Cited
2010
In vitro anti-trypanosomal activity of elatol isolated from red seaweed Laurencia dendroidea
SUMMARY Chagas' disease is a debilitating but comparatively neglected illness that affects about 15 million people. There is an… Expand
Highly Cited
2010
Highly Cited
2010
Effect of Elatol, Isolated from Red Seaweed Laurencia dendroidea, on Leishmania amazonensis
In the present study, we investigated the antileishmanial activity of sesquiterpene elatol, the major constituent of the… Expand
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Highly Cited
2008
Highly Cited
2008
The catalytic asymmetric total synthesis of elatol.
Described in this report is the first total synthesis of elatol, a halogenated sesquiterpene in the chamigrene natural product… Expand
2006
2006
Quantitative GC-ECD Analysis of Halogenated Metabolites: Determination of Surface and Within-Thallus Elatol of Laurencia obtusa
Information on natural concentrations or variability of secondary metabolites in marine organisms may be important both to… Expand
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Highly Cited
2003
Highly Cited
2003
Potent antibacterial activity of halogenated metabolites from Malaysian red algae, Laurencia majuscula (Rhodomelaceae, Ceramiales).
Red algae genus Laurencia (Rhodomelaceae, Ceramiales) are known to produce a wide range of chemically interesting secondary… Expand
Highly Cited
2001
Highly Cited
2001
Antibacterial halogenated metabolites from the Malaysian Laurencia species.
Two halogenated C15 acetogenins, named lembyne-A and lembyne-B, have been isolated from an unrecorded Laurencia species collected… Expand
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