FAQ

dystroglycan binding

Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues… (More)

Topic mentions per year

Topic mentions per year

1995-2017
02419952017

Papers overview

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2006
2006
Binding of laminin alpha1-chain LG4-5 domain to alpha-dystroglycan causes tyrosine phosphorylation of syntrophin to initiate Rac1 signaling.
Previously, a signaling pathway was described [Oak, Zhou, and Jarrett (2003) J. Biol. Chem. 278, 39287-39295] that links matrix… (More)
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2004
2004
Molecular dissection of the alpha-dystroglycan- and integrin-binding sites within the globular domain of human laminin-10.
The adhesive interactions of cells with laminins are mediated by integrins and non-integrin-type receptors such as alpha… (More)
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2003
2003
Distinct requirements for heparin and alpha-dystroglycan binding revealed by structure-based mutagenesis of the laminin alpha2 LG4-LG5 domain pair.
Laminin-2 (alpha2beta1gamma1) is found in basement membranes surrounding muscle and peripheral nerve cells. Several types of… (More)
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2003
2003
Beta1 integrin and alpha-dystroglycan binding sites are localized to different laminin-G-domain-like (LG) modules within the laminin alpha5 chain G domain.
Laminins are a group of extracellular-matrix proteins important in development and disease. They are heterotrimers, and specific… (More)
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2002
2002
Inhibition of dystroglycan binding to laminin disrupts the PI3K/AKT pathway and survival signaling in muscle cells.
Dystroglycan is a component of the dystrophin-glycoprotein complex (DGC) in muscle and a cell surface receptor for laminin… (More)
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2001
2001
Identification of the beta-dystroglycan binding epitope within the C-terminal region of alpha-dystroglycan.
Dystroglycan is a receptor for extracellular matrix proteins that plays a crucial role during embryogenesis in addition to adult… (More)
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Highly Cited
1999
Highly Cited
1999
The crystal structure of a laminin G-like module reveals the molecular basis of alpha-dystroglycan binding to laminins, perlecan, and agrin.
Laminin G-like (LG) modules in the extracellular matrix glycoproteins laminin, perlecan, and agrin mediate the binding to heparin… (More)
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1999
1999
WW and EF hand domains of dystrophin-family proteins mediate dystroglycan binding.
The membrane-spanning dystrophin glycoprotein complex mediates an indirect linkage between the actin-based cytoskeleton and the… (More)
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1999
1999
Mutation of a basic sequence in the laminin alpha2LG3 module leads to a lack of proteolytic processing and has different effects on beta1 integrin-mediated cell adhesion and alpha-dystroglycan…
A RRKRRQ sequence unique to the LG3 module of the laminin alpha2 chain was previously shown to be sensitive to endogenous… (More)
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1996
1996
Differential heparin inhibition of skeletal muscle alpha-dystroglycan binding to laminins.
The laminin binding properties of alpha-dystroglycan purified from rabbit skeletal muscle membranes were examined. In a solid… (More)
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