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duocarmycin B2

 
National Institutes of Health

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2016
2016
To evaluate the reactivity of antitumor agents in a nucleosome architecture, we conducted in vitro studies to assess the… Expand
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2004
2004
Background: KW-2189 is a semi-synthetic, water-soluble analog of duocarmycin B2, a new class of potent antitumor antibiotics… Expand
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1998
1998
The duocarmycins represent a new group of antitumor antibiotics produced by Streptomyces that bind to the minor groove of DNA. KW… Expand
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1996
1996
Several A-ring pyrrole derivatives of duocarmycin B2 were synthesized effectively from the 3-hydroxy compounds by utilizing an… Expand
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1996
1996
A series of the eight-substituted A-ring pyrrole derivatives of duocarmycin B2 were synthesized, and evaluated for in vitro… Expand
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1995
1995
A series of duocarmycin B2 derivatives, modified at the phenolic hydroxyl group to ester, carbonate and carbamate, was… Expand
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1994
1994
Methyl(1S)-1-bromomethyl-7-methyl-5-[(4-methylpiperazinyl)-carb onyloxy]- 3-[(5,6,7-trimethoxy-2-indolyl)-carbonyl]-1,2-dihydro… Expand
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