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drug export

The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, out of a cell or organelle. [GOC… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Replacing the eleven native tryptophans by directed evolution produces an active P-glycoprotein with site-specific, non-conservative substitutions
P-glycoprotein (Pgp) pumps an array of hydrophobic compounds out of cells, and has major roles in drug pharmacokinetics and… 
2017
2017
Usefulness of the MRP 2 promoter to overcome the chemoresistance of gastrointestinal and liver tumors by enhancing the expression of the drug transporter OATP 1 B 1
Tumor response to chemotherapy is often limited by drug export through ABC proteins. To overcome this problem, here we have… 
2013
2013
PP124—Pharmacokinetics of tolperisone in relation to CYP2C19 genotypes
2013
2013
PP126—In-vitro reactivity of drug-specific t-cells from a HLA-A*31:01 positive carbamazepine hypersensitive patient
2012
2012
Effects of Kampo medicines on MDR-1-mediated multidrug resistance in human hepatocellular carcinoma HuH-7/PTX cells.
Paclitaxel-resistant HuH-7 (HuH-7/PTX) cells were established by one-week exposure of HuH-7 cells to paclitaxel to analyze the… 
2010
2010
Site-directed disulfide cross-linking to probe conformational changes of a transporter during its functional cycle: Escherichia coli AcrB multidrug exporter as an example.
Many proteins, especially transporters, are thought to undergo large conformational alterations during their functional cycle… 
Review
2009
Review
2009
Overview of the molecular bases of resistance to chemotherapy in liver and gastrointestinal tumours.
Primary malignancies of the liver and the gastrointestinal tract constitute one of the main health problems worldwide. Together… 
2006
2006
Stimulation of P-glycoprotein ATPase by analogues of tetramethylrosamine: coupling of drug binding at the "R" site to the ATP hydrolysis transition state.
The multidrug resistance efflux pump P-glycoprotein (Pgp) couples drug export to ATP binding and hydrolysis. Details regarding… 
Highly Cited
2002
Highly Cited
2002
ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms
1995
1995
Cocaine Prohibition: Drug-Induced Madness in the Western Hemisphere
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