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drug development

Known as: development drug, development drugs 
Design, identification, synthesis, extraction, purification, modification, or characterization of potential anticancer agents; studies of their… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
nature medicine volume 19 | number 5 | may 2013 515 Life is short—especially for children with Hutchinson-Gilford progeria… Expand
Review
2011
Review
2011
SummaryThe blood-brain barrier (BBB) is formed by the brain capillary endothelium and excludes from the brain ∼100% of large… Expand
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Review
2010
Review
2010
Membrane transporters can be major determinants of the pharmacokinetic, safety and efficacy profiles of drugs. This presents… Expand
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Review
2010
Review
2010
Alzheimer's disease is the most common cause of dementia in elderly people. Research into Alzheimer's disease therapy has been at… Expand
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Review
2003
Review
2003
The research and development costs of 68 randomly selected new drugs were obtained from a survey of 10 pharmaceutical firms… Expand
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Review
2003
Review
2003
OBJECTIVE To attempt to determine the relative value of preclinical cardiac electrophysiology data (in vitro and in vivo) for… Expand
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Review
2000
Review
2000
New information regarding neuronal circuits that control food intake and their hormonal regulation has extended our understanding… Expand
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Review
1999
Review
1999
The plethora of failed clinical trials with neuroprotective drugs for acute ischemic stroke have raised justifiable concerns… Expand
Review
1995
Review
1995
Protein tyrosine kinases (PTKs) regulate cell proliferation, cell differentiation, and signaling processes in the cells of the… Expand
Highly Cited
1978
Highly Cited
1978
By means of the maximal electroshock seizure (MES) test, the subcutaneous pentylenetetrazol (PTZ) seizure threshold test, and the… Expand