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drug development

Known as: development drug, development drugs 
Design, identification, synthesis, extraction, purification, modification, or characterization of potential anticancer agents; studies of their… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
The blood-brain barrier: Bottleneck in brain drug development
SummaryThe blood-brain barrier (BBB) is formed by the brain capillary endothelium and excludes from the brain ∼100% of large… 
Review
2010
Review
2010
Membrane transporters in drug development
Membrane transporters can be major determinants of the pharmacokinetic, safety and efficacy profiles of drugs. This presents… 
Highly Cited
2008
Highly Cited
2008
Microscale culture of human liver cells for drug development
Tissue function depends on hierarchical structures extending from single cells (∼10 μm) to functional subunits (100 μm–1 mm) that… 
Highly Cited
2007
Highly Cited
2007
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an… 
Review
2007
Review
2007
The serotonin signaling system: from basic understanding to drug development for functional GI disorders.
Serotonin is an important gastrointestinal signaling molecule. It is a paracrine messenger utilized by enterochromaffin (EC… 
Review
2003
Review
2003
The price of innovation: new estimates of drug development costs.
Review
2000
Review
2000
Central nervous system control of food intake
New information regarding neuronal circuits that control food intake and their hormonal regulation has extended our understanding… 
Review
1999
Review
1999
Recommendations for standards regarding preclinical neuroprotective and restorative drug development.
The plethora of failed clinical trials with neuroprotective drugs for acute ischemic stroke have raised justifiable concerns… 
Review
1995
Review
1995
Tyrosine kinase inhibition: an approach to drug development.
Protein tyrosine kinases (PTKs) regulate cell proliferation, cell differentiation, and signaling processes in the cells of the… 
Highly Cited
1978
Highly Cited
1978
Antiepileptic Drug Development: II. Anticonvulsant Drug Screening
By means of the maximal electroshock seizure (MES) test, the subcutaneous pentylenetetrazol (PTZ) seizure threshold test, and the… 
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