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dopachrome isomerase activity

Known as: TRP2, dopachrome delta7,Delta2-isomerase activity, dopachrome-rearranging enzyme 
Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate. [EC:5.3.3.12, RHEA:13044]
National Institutes of Health

Related topics

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7 relations
D-dopachrome decarboxylase activityDCT geneDCT protein, humanDopachrome isomerase
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Broader (1)

Isomerase

Papers overview

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Highly Cited
2011
Highly Cited
2011
The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)
Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the immune response. Neutralization or genetic deletion of… Expand
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Highly Cited
2004
Highly Cited
2004
Direct interaction of Sox10 with the promoter of murine Dopachrome Tautomerase (Dct) and synergistic activation of Dct expression with Mitf.
The murine dopachrome tautomerase (Dct) gene is expressed early in melanocyte development during embryogenesis, prior to other… Expand
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Highly Cited
2004
Highly Cited
2004
Melanocytes and pigmentation are affected in dopachrome tautomerase knockout mice.
The tyrosinase family comprises three members, tyrosinase (Tyr), tyrosinase-related protein 1 (Tyrp1), and dopachrome tautomerase… Expand
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Review
2003
Review
2003
Microphthalmia-associated transcription factor in the Wnt signaling pathway.
Microphthalmia-associated transcription factor (MITF) contains a basic helix-loop-helix and leucine-zipper (bHLH-LZ) structure… Expand
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Highly Cited
2001
Highly Cited
2001
A model for melanosome biogenesis based on the purification and analysis of early melanosomes
Melanosome biogenesis and function were studied after purification of early stage melanosomes and characterization of specific… Expand
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Highly Cited
2001
Highly Cited
2001
Analysis of SOX10 function in neural crest-derived melanocyte development: SOX10-dependent transcriptional control of dopachrome tautomerase.
SOX10 is a high-mobility-group transcription factor that plays a critical role in the development of neural crest-derived… Expand
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Highly Cited
1998
Highly Cited
1998
Structure and organization of the human theta-class glutathione S-transferase and D-dopachrome tautomerase gene complex.
The structure and organization of the human Theta-class glutathione S-transferase (GST) genes have been determined. GSTT1 and… Expand
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Highly Cited
1994
Highly Cited
1994
Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase.
Melanin production is a major virulence factor for Cryptococcus neoformans, an organism causing life-threatening infections in an… Expand
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1994
1994
Cloning of the human DOPAchrome tautomerase/tyrosinase-related protein 2 gene and identification of two regulatory regions required for its pigment cell-specific expression.
We have cloned and sequenced the human genomic DNA segments encoding the 5'-flanking region and the first two exons of the… Expand
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Highly Cited
1993
Highly Cited
1993
Melanogenesis during the anagen-catagen-telogen transformation of the murine hair cycle.
Melanin synthesis of follicular melanocytes is strictly coupled to the growth stage of the hair cycle (anagen), ceases during… Expand
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