Skip to search formSkip to main contentSkip to account menu

dirlotapide

Known as: 5-((4'-trifluoromethyl-biphenyl-2-carbonyl)-amino)-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

CarbamatesIndoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide.
Review
2007
Review
2007
Dirlotapide: a review of its properties and role in the management of obesity in dogs.
Dirlotapide is a microsomal triglyceride transfer protein (MTP) inhibitor developed specifically for canine weight reduction. MTP… 
2007
2007
Biologic activity of dirlotapide, a novel microsomal triglyceride transfer protein inhibitor, for weight loss in obese dogs.
Dirlotapide is a novel microsomal triglyceride transfer protein inhibitor intended for the treatment and management of obesity in… 
Review
2007
Review
2007
Canine obesity: an overview.
Canine patients are generally regarded as being clinically obese when their body weight is at least 15% above ideal. The… 
2007
2007
The safety of dirlotapide in dogs.
The safety of dirlotapide in dogs was evaluated in two studies with parallel designs. In an acute tolerance study, 24 beagles… 
2007
2007
Absorption, distribution, metabolism, and excretion of dirlotapide in the dog.
Three once-daily oral doses of 0.2 mg/kg [(14)C]dirlotapide were administered to beagle dogs to study the absorption… 
2007
2007
Influence of dirlotapide, a microsomal triglyceride transfer protein inhibitor, on the digestibility of a dry expanded diet in adult dogs.
The objectives of this study were to evaluate the effects of dirlotapide, a microsomal triglyceride transfer protein inhibitor… 
Review
2007
Review
2007
Pharmacokinetics of dirlotapide in the dog.
An overview of the pharmacokinetics of dirlotapide in beagle dogs is presented. The following mean parameters were observed after… 
2007
2007
In vitro and in vivo profile of 5-[(4'-trifluoromethyl-biphenyl-2-carbonyl)-amino]-1H-indole-2-carboxylic acid benzylmethyl carbamoylamide (dirlotapide), a novel potent MTP inhibitor for obesity.
Review
2007
Review
2007
Dirlotapide, a U.S. Food and Drug Administration-Approved First-in-Class Obesity Drug for Dogs—Will Humans Be Next?
On January 5, 2007 the U.S. Food and Drug Administration (FDA) approved the diet drug dirlotapide (Slentrol, Pfizer Inc., New… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)