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diphthine

Known as: 1H-Imidazole-2-propanaminium, 4-(2-amino-2-carboxyethyl)-alpha-carboxy-N,N,N-trimethyl-, hydroxide, inner salt 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Histidine
analogs & derivatives

Papers overview

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2016
2016
Structures, Properties, and Dynamics of Intermediates in eEF2-Diphthamide Biosynthesis
The eukaryotic translation Elongation Factor 2 (eEF2) is an essential enzyme in protein synthesis. eEF2 contains a unique… 
2014
2014
Decoding the biosynthesis and function of diphthamide, an enigmatic modification of translation elongation factor 2 (EF2)
Diphthamide is a highly conserved modification of archaeal and eukaryal translation elongation factor 2 (EF2) and yet why cells… 
2008
2008
Systematic study on crystal-contact engineering of diphthine synthase: influence of mutations at crystal-packing regions on X-ray diffraction quality.
It is well known that protein crystallizability can be influenced by site-directed mutagenesis of residues on the molecular… 
Highly Cited
1988
Highly Cited
1988
Biosynthesis of diphthamide in Saccharomyces cerevisiae. Partial purification and characterization of a specific S-adenosylmethionine:elongation factor 2 methyltransferase.
Highly Cited
1984
Highly Cited
1984
In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin
Diphthamide, a unique amino acid, is a post-translational derivative of histidine that exists in protein synthesis elongation… 
1983
1983
Biosynthetic labeling of diphthamide in Saccharomyces cerevisiae.
Highly Cited
1983
Highly Cited
1983
Occurrence of diphthamide in archaebacteria
We examined the nature of the diphtheria toxin fragment A recognition site in the protein synthesis translocating factor present… 
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