dipetarudin
National Institutes of Health
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Summary Dipetarudin was coupled to polyethylene glycol (PEG)-5000 residues in order to improve its pharmacokinetic profile and to…
Dipetarudin, ein chimarer, bivalenter, direkter Thrombininhibitor aus dem N-terminalen Bereich des Dipetalogastins II aus der…
Summary Protease specificity is crucial to the design of thrombin inhibitors as inhibition of other physiologically relevant…
Summary The structure-activity relationship of dipetalogastin II, the strongest thrombin inhibitor isolated and cloned from the…
Thrombin is a potent mitogen for many tumor cells, suggesting that this enzyme may be involved in tumor genesis and metastasis…
Dipetarudin is a hybrid thrombin inhibitor composed of the N-terminal structure of dipetalogastin II and the exosite 1 blocking…