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dimethylargininase activity

Known as: N(G),N(G)-dimethylarginine dimethylaminohydrolase activity, NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity, dimethylarginine dimethylaminohydrolase activity 
Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. [EC:3.5.3.18]
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Asymmetric dimethylarginine (ADMA) — a naturally occurring amino acid that is a product of protein breakdown — is released into… 
Highly Cited
2008
Highly Cited
2008
OBJECTIVE—The nitric oxide (NO) synthase inhibitor asymmetric dimethylarginine (ADMA) is generated by protein arginine N… 
Highly Cited
2003
Highly Cited
2003
Background—Experimental evidence suggests that estrogens stimulate the production of nitric oxide (NO) by vascular endothelial… 
Highly Cited
2002
Highly Cited
2002
The enzyme dimethylarginine dimethylaminohydrolase (DDAH) hydrolyses asymmetrically methylated arginine residues that are… 
Highly Cited
2001
Highly Cited
2001
Background—Hyperhomocysteinemia is a putative risk factor for cardiovascular disease, which also impairs endothelium-dependent… 
Highly Cited
2001
Highly Cited
2001
Nitric oxide synthase is inhibited by asymmetric NG-methylated derivatives of arginine whose cellular levels are controlled in… 
Highly Cited
2000
Highly Cited
2000
l-Citrulline constitutes a product of a number of enzymatic reactions. In the past a number of colorimetric methods for the… 
Highly Cited
2000
Highly Cited
2000
Endogenously produced asymmetrically methylated arginine residues are competitive inhibitors of all three isoforms of nitric… 
Highly Cited
1996
Highly Cited
1996
1 Dimethylarginine dimethylaminohydrolase (DDAH), an enzyme that metabolizes the endogenous nitric oxide synthase inhibitors NG…