FAQ

dimethylargininase activity

Known as: N(G),N(G)-dimethylarginine dimethylaminohydrolase activity, NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity, dimethylarginine dimethylaminohydrolase activity 
Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline. [EC:3.5.3.18]
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2015
01220022015

Papers overview

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2016
2016
Vascular peroxidase 1 up regulation by angiotensin II attenuates nitric oxide production through increasing asymmetrical dimethylarginine in HUVECs.
Asymmetric dimethylarginine (ADMA), the endogenous inhibitor of nitric oxide synthase, contributes to endothelial dysfunction and… (More)
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2013
2013
Estradiol, acting through estrogen receptor alpha, restores dimethylarginine dimethylaminohydrolase activity and nitric oxide production in oxLDL-treated human arterial endothelial cells.
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) synthase. ADMA accumulation, mainly due to a… (More)
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2012
2012
Role of dimethylarginine dimethylaminohydrolase activity in regulation of tissue and plasma concentrations of asymmetric dimethylarginine in an animal model of prolonged critical illness.
High plasma concentrations of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are associated… (More)
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2007
2007
Determination of dimethylarginine dimethylaminohydrolase activity in the kidney.
Dimethylarginine dimethylaminohydrolase (DDAH) metabolizes asymmetric dimethylarginine to generate L-citrulline and is present in… (More)
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2006
2006
No compensatory upregulation of placental dimethylarginine dimethylaminohydrolase activity in preeclampsia.
BACKGROUND/AIMS Placental dysfunction of the asymmetric dimethylarginine (ADMA) degrading enzyme dimethylarginine… (More)
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2006
2006
L-arginine regulates asymmetric dimethylarginine metabolism by inhibiting dimethylarginine dimethylaminohydrolase activity in hepatic (HepG2) cells
An increase in circulating asymmetric dimethylarginine (ADMA) and a decreased L-arginine/ADMA ratio are associated with reduced… (More)
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2006
2006
Determination of NG,NG-dimethyl-L-arginine in rat plasma and dimethylarginine dimethylaminohydrolase activity in rat kidney using a monolithic silica column.
A fast, simple and sensitive column-switching high-performance liquid chromatography (HPLC)-fluorescence detection method was… (More)
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2005
2005
Accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, attenuated dimethylarginine dimethylaminohydrolase activity and intimal hyperplasia in premenopausal human uterine…
The present study was designed to investigate the involvement of nitric oxide synthase (NOS), endogenous NOS inhibitors, arginase… (More)
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2003
2003
Estrogen stimulates dimethylarginine dimethylaminohydrolase activity and the metabolism of asymmetric dimethylarginine.
BACKGROUND Experimental evidence suggests that estrogens stimulate the production of nitric oxide (NO) by vascular endothelial… (More)
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2002
2002
Dimethylarginine dimethylaminohydrolase I enhances tumour growth and angiogenesis
Angiogenesis is a prerequisite for tumour progression and is highly regulated by growth factors and cytokines a number of which… (More)
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