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dideoxyribonucleoside methylphosphonates

Known as: MATAGEN, DDRNMP, methylphosphonate oligodeoxynucleosides 
National Institutes of Health

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Oligodeoxyribonucleotides

Papers overview

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Highly Cited
1991
Highly Cited
1991
Antisense inhibition of ras p21 expression that is sensitive to a point mutation.
Many genetic disorders result from a single point mutation, and many tumor oncogenes have been found to be altered by a point… 
1991
1991
Solid phase synthesis of oligodeoxyribonucleoside phosphorodithioates from thiophosphoramidites.
Oligonucleoside phosphorodithioates 1 are modified DNA sequences with potential use as antisense oligonucleotides. The… 
Highly Cited
1988
Highly Cited
1988
Antisense DNA and RNA: progress and prospects.
Using antisense DNA or RNA fragments to block the expression of selected genes, and thereby assess their function, is a powerful… 
Review
1987
Review
1987
A new approach to chemotherapy based on molecular biology and nucleic acid chemistry: Matagen (masking tape for gene expression).
The nucleotide sequences of genes contain information which can potentially be used to understand gene function and thus the… 
1987
1987
Oligodeoxyribonucleoside methylphosphonates. NMR and UV spectroscopic studies of Rp-Rp and Sp-Sp methylphosphonate (Me) modified duplexes of (d[GGAATTCC])2.
1H NMR chemical shift assignments for the title compounds were made for most of the 1H signals using two-dimensional nuclear… 
Review
1987
Review
1987
An Approach to Chemotherapy Based on Base Sequence Information and Nucleic Acid Chemistry Matagen (Masking Tape for Gene Expression)
Advances in modern biological research reveal that the properties and behavior of living organisms are governed by their genes… 
Highly Cited
1986
Highly Cited
1986
Inhibition of vesicular stomatitis virus protein synthesis and infection by sequence-specific oligodeoxyribonucleoside methylphosphonates.
Oligodeoxyribonucleoside methylphosphonates which have sequences complementary to the initiation codon regions of N, NS, and G… 
Highly Cited
1986
Highly Cited
1986
Solid-phase syntheses of oligodeoxyribonucleoside methylphosphonates.
Oligodeoxyribonucleoside methylphosphonates of defined sequence of the type d-Np(NP)nN, where n is 6-13, are readily prepared on… 
Highly Cited
1985
Highly Cited
1985
Characterization of sequence-specific oligodeoxyribonucleoside methylphosphonates and their interaction with rabbit globin mRNA.
Oligodeoxynucleoside methylphosphonates, nucleic acid analogues that contain nonionic, 3'-5'-linked methylphosphonate… 
1983
1983
Preparation of oligodeoxyribonucleoside methylphosphonates on a polystyrene support.
An efficient procedure is described for synthesizing deoxyribonucleoside methylphosphonates on polystyrene polymer supports which… 
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