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deoxynyboquinone

National Institutes of Health

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Quinones

Papers overview

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2017
2017
Distinct responses of compartmentalized glutathione redox potentials to pharmacologic quinones targeting NQO1.
2015
2015
Abstract P6-02-02: Exploiting Isobutyl-deoxynyboquinone-induced DNA damage responses and metabolic changes for breast cancer therapy
During oncogenic or cellular stress new genes are frequently (over)-expressed that could be exploited for targeted cancer therapy… 
2014
2014
Deoxynyboquinone and its derivatives upregulate glutathione‐specific genes in MDA‐MB‐231 breast cancer cells (655.10)
Pharmacological activation of genes encoding antioxidant and/or phase 2 detoxifying enzymes offer a promising approach to… 
2014
2014
Abstract 1679: Inhibiting KRAS-reprogrammed glutamine metabolism sensitizes pancreatic cancer to NQO1-bioactivatable drugs
Patients with pancreatic cancers have one of the highest mortality rates of any cancer with 5-year survival rates of 6%. The… 
2012
2012
Therapeutics , Targets , and Chemical Biology An NQO 1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP 1-Induced Programmed Necrosis
Agents, such as b-lapachone, that target the redox enzyme, NAD(P)H:quinone oxidoreductase 1 (NQO1), to induce programmed necrosis… 
2012
2012
496 Targeting NQO1 as a Potential Anticancer Strategy Using the Small Molecule Deoxynyboquinone
2012
2012
The development of deoxynyboquinone as a personalized anticancer compound
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