dendritic spine maintenance
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Perturbation of synapse development underlies many inherited neurodevelopmental disorders including intellectual disability (ID… Expand Calcineurin inhibitors may prevent amyloid-induced progression of Alzheimer’s disease by preventing suppression of the isomerase… Expand Dendritic spines are a morphological feature of the majority of excitatory synapses in the mammalian neocortex and are motile… Expand Dendritic spine stabilization depends on afferent synaptic input and requires changes in actin cytoskeleton dynamics and protein… Expand Alzheimer's disease (AD) is characterized by a wide loss of synapses and dendritic spines. Despite extensive efforts, the… Expand Tetanus toxin light chain has been used for some time as a genetically-encoded tool to inhibit neurotransmission and thereby… Expand Diacylglycerol (DAG) is an important signaling molecule at neuronal synapses. Generation of synaptic DAG is triggered by the… Expand BACKGROUND
Recent studies on GTPases have suggested that reduced Duo and cell division cycle 42 (Cdc42) transcript expression is… Expand Diacylglycerol (DAG) is an important lipid signalling molecule that exerts an effect on various effector proteins including… Expand Dendritic spines are highly dynamic protuberances that are thought to be crucial for learning and memory. Although it is well… Expand