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deltarasin

 
National Institutes of Health

Papers overview

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2019
2019
Tumours manage to survive the ablation of mutant KRAS, despite the development of KRAS-targeted drugs. Here we describe that… Expand
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2018
2018
Rap1 proteins are members of the Ras subfamily of small GTPases involved in many biological responses, including adhesion, cell… Expand
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2018
2018
Hepatocellular carcinoma (HCC) represents a serious and urgent global health problem because of its increasing incidence and the… Expand
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2017
2017
Deltarasin is a recently identified small molecule that can inhibit KRAS–PDEδ interactions by binding to a hydrophobic pocket on… Expand
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2017
2017
Objective Sorafenib is the only effective therapy for advanced hepatocellular carcinoma (HCC). Combinatory approaches targeting… Expand
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2017
2017
Malignant pleural effusion (MPE) is the lethal consequence of various human cancers metastatic to the pleural cavity. However… Expand
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2017
2017
Plasma membrane (PM) localization of Ras proteins is crucial for transmitting signals upon mitogen stimulation. Post… Expand
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Highly Cited
2016
Highly Cited
2016
The prenyl-binding protein PDEδ is crucial for the plasma membrane localization of prenylated Ras. Recently, we have reported… Expand
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2015
2015
e13597 Background: As oncogenic KRAS relies on the correct spatial localization to exert its function, disrupting the transport… Expand
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2013
2013
  • Man Tsuey Tse
  • Nature Reviews Drug Discovery
  • 2013
  • Corpus ID: 10494295
has yielded potent small-molecule compounds that directly disrupt the signalling of oncogenic KRAS through a new target… Expand
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