Semantic Scholar uses AI to extract papers important to this topic.
Tumours manage to survive the ablation of mutant KRAS, despite the development of KRAS-targeted drugs. Here we describe that… Expand Hepatocellular carcinoma (HCC) represents a serious and urgent global health problem because of its increasing incidence and the… Expand Rap1 proteins are members of the Ras subfamily of small GTPases involved in many biological responses, including adhesion, cell… Expand Deltarasin is a recently identified small molecule that can inhibit KRAS–PDEδ interactions by binding to a hydrophobic pocket on… Expand Objective Sorafenib is the only effective therapy for advanced hepatocellular carcinoma (HCC). Combinatory approaches targeting… Expand Malignant pleural effusion (MPE) is the lethal consequence of various human cancers metastatic to the pleural cavity. However… Expand Plasma membrane (PM) localization of Ras proteins is crucial for transmitting signals upon mitogen stimulation. Post… Expand The prenyl-binding protein PDEδ is crucial for the plasma membrane localization of prenylated Ras. Recently, we have reported… Expand Oncogenic mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS) occur in 15%-30% of non-small cell lung cancer (NSCLC… Expand e13597 Background: As oncogenic KRAS relies on the correct spatial localization to exert its function, disrupting the transport… Expand