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deltarasin

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Tumours manage to survive the ablation of mutant KRAS, despite the development of KRAS-targeted drugs. Here we describe that… 
2018
2018
Hepatocellular carcinoma (HCC) represents a serious and urgent global health problem because of its increasing incidence and the… 
2018
2018
Rap1 proteins are members of the Ras subfamily of small GTPases involved in many biological responses, including adhesion, cell… 
Highly Cited
2017
Highly Cited
2017
Objective Sorafenib is the only effective therapy for advanced hepatocellular carcinoma (HCC). Combinatory approaches targeting… 
2017
2017
Deltarasin is a recently identified small molecule that can inhibit KRAS–PDEδ interactions by binding to a hydrophobic pocket on… 
Highly Cited
2017
Highly Cited
2017
Malignant pleural effusion (MPE) is the lethal consequence of various human cancers metastatic to the pleural cavity. However… 
2017
2017
Plasma membrane (PM) localization of Ras proteins is crucial for transmitting signals upon mitogen stimulation. Post… 
Highly Cited
2016
Highly Cited
2016
The prenyl-binding protein PDEδ is crucial for the plasma membrane localization of prenylated Ras. Recently, we have reported… 
Review
2016
Review
2016
Oncogenic mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS) occur in 15%-30% of non-small cell lung cancer (NSCLC… 
2015
2015
e13597 Background: As oncogenic KRAS relies on the correct spatial localization to exert its function, disrupting the transport…