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degrasyn

Known as: 2-cyano-N-(1-phenylbutyl)-3-(6-bromopyridin-2-yl)acrylamide, WP1130 
 
National Institutes of Health

Papers overview

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2017
2017
The deubiquitinase USP5 stabilizes c-Maf, a key transcription factor in multiple myeloma (MM), but the mechanisms and… Expand
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2016
2016
It remains a challenge in oncology to identify novel drug regimens to efficiently tackle glioblastoma, the most common primary… Expand
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2015
2015
Antiestrogen resistance is a major problem in breast cancer treatment. Therefore, the search for new therapeutic targets and… Expand
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2015
2015
Resistance to chemotherapeutic drugs is a major obstacle in hepatocellular carcinoma (HCC) therapy. However, the underlying… Expand
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2015
2015
Autophagy represents an intracellular degradation process which is involved in both regular cell homeostasis and disease settings… Expand
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Highly Cited
2014
Highly Cited
2014
Significance The transcription factor E-twenty-six related gene (ERG) is a major driver of prostate cancer, which makes this… Expand
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2012
2012
Ubiquitin (Ub) is a vital regulatory component in various cellular processes, including cellular responses to viral infection. As… Expand
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Highly Cited
2010
Highly Cited
2010
Recent evidence suggests that several deubiquitinases (DUB) are overexpressed or activated in tumor cells and many contribute to… Expand
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2010
2010
Mantle cell lymphoma (MCL) is an aggressive histotype of B-cell non–Hodgkin lymphoma that has increased in incidence over the… Expand
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2007
2007
c-Myc is a highly unstable transcription factor whose deregulation and increased expression are associated with cancer. Degrasyn… Expand
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