decidium

 
National Institutes of Health

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Phenanthridines

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2005
2005
Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE.
The peripheral anionic site on acetylcholinesterase (AChE), located at the active site gorge entry, encompasses overlapping… (More)
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Highly Cited
2003
Highly Cited
2003
Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site.
The peripheral anionic site on acetylcholinesterase (AChE), located at the active center gorge entry, encompasses overlapping… (More)
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1992
1992
Interaction of tetrahydroaminoacridine with acetylcholinesterase and butyrylcholinesterase.
This paper examines inhibition of acetylcholinesterase (AchE) and butyrylcholinesterase (BuchE) by tetrahydroaminoacridine (THA… (More)
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1989
1989
Chiral nature of covalent methylphosphonyl conjugates of acetylcholinesterase.
This paper examines the chiral nature of the covalent conjugates formed upon reaction of acetylcholinesterase (AchE) with… (More)
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1987
1987
Decidium. A novel fluorescent probe of the agonist/antagonist and noncompetitive inhibitor sites on the nicotinic acetylcholine receptor.
We have examined the interaction of the nicotinic acetylcholine receptor with decidium diiodide, a bisquaternary analogue of… (More)
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1987
1987
Site selectivity of fluorescent bisquaternary phenanthridinium ligands for acetylcholinesterase.
The synthesis of decidium and hexidium diiodides, their spectroscopic properties, and association with acetylcholinesterase from… (More)
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1986
1986
Kinetic, equilibrium, and spectroscopic studies on dealkylation ("aging") of alkyl organophosphonyl acetylcholinesterase. Electrostatic control of enzyme topography.
The mechanism of dealkylation ("aging") of branched-alkyl organophosphonyl conjugates of acetylcholinesterase and the consequence… (More)
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1986
1986
Kinetic, equilibrium and spectroscopic studies on cation association at the active center of acetylcholinesterase: topographic distinction between trimethyl and trimethylammonium sites.
This study examines the importance of electrostatic interactions on ligand association at the active center of… (More)
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1985
1985
Spatial Relationships between Drug Binding Sites on the Surface of the Acetylcholine Receptor: Preparation and Interaction of Fluorescent Alpha-Toxins and Decidium with the Acetylcholine Receptor
Abstract : This report described the development of fluorescent probes of the nicotinic acetylcholine receptor and their use in… (More)
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