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debromohymenialdisine

Known as: DBHA-SKF 
 
National Institutes of Health

Papers overview

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2010
2010
Background and purpose:  Checkpoint kinase 2 (CHK2) is activated by DNA damage and can contribute to p53 stabilization… Expand
2010
2010
Sponges (Porifera), as the best known source of bioactive marine natural products in metazoans, play a significant role in marine… Expand
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Highly Cited
2009
Highly Cited
2009
BackgroundSubsets of cells with stem-like properties have been previously isolated from human epithelial cancers and their… Expand
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Highly Cited
2008
Highly Cited
2008
Atypical teratoid/rhabdoid tumor (AT/RT) is an extremely malignant neoplasm in the central nervous system (CNS) which occurs in… Expand
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Highly Cited
2007
Highly Cited
2007
Chk2 is a protein kinase involved in the ATM-dependent checkpoint pathway (http://discover.nci.nih.gov/mim). This pathway is… Expand
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Highly Cited
2006
Highly Cited
2006
The protein kinase Chk2 (checkpoint kinase 2) is a major effector of the replication checkpoint. Chk2 activation is initiated by… Expand
Highly Cited
2004
Highly Cited
2004
The marine sponge metabolite hymenialdisine is a potent inhibitor of a variety of kinases including MEK-1, GSK-3 beta, and CK1… Expand
Highly Cited
2002
Highly Cited
2002
Raf/MEK-1/MAPK cascade inhibitor activity-directed fractionation of the sponge Stylissa massa afforded eight known alkaloids… Expand
Highly Cited
2001
Highly Cited
2001
Cells can respond to DNA damage by activating checkpoints that delay cell cycle progression and allow time for DNA repair… Expand
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1997
1997
The synthesis of C(11)N(5) marine sponge alkaloids (+/-)-hymenin (1), stevensine (2), hymenialdisine (3), and… Expand