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debromohymenialdisine

Known as: DBHA-SKF 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AzepinesPyrroles

Narrower (1)

SK&F 108753

Papers overview

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2012
2012
Synthesis and evaluation of debromohymenialdisine-derived Chk2 inhibitors.
2012
2012
Comparative Study of Morphological and Molecular Characters Between Two Sponge Specimens (Porifera: Demosponge: Axinella) with Pharmacologically Active Compounds from the South China Sea
The Phylum Porifera is an economically important group of marine animals. Considerable research and development has been done for… 
2010
2010
Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors
Background and purpose:  Checkpoint kinase 2 (CHK2) is activated by DNA damage and can contribute to p53 stabilization… 
2008
2008
Cellular localization and quantification of bioactive alkaloids hymenialdisine and debromohymenialdisine in marine sponge Axinella sp.
Sponges, as the best-known source of bioactive marine natural products inmetazoan, play a significant role in marine drug… 
2006
2006
Design and synthesis of diazepine inhibitors as novel anti-cancer agents
Cancer is a new growth that arises from abnormal and uncontrolled division of cells that may go on to invade and destroy… 
2003
2003
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
Activation of Cdc2/cyclin B kinase and entry into mitosis requires dephosphorylation of inhibitory sites on Cdc2 by Cdc25… 
Highly Cited
2001
Highly Cited
2001
Inhibition of the G2 DNA Damage Checkpoint and of Protein Kinases Chk1 and Chk2 by the Marine Sponge Alkaloid Debromohymenialdisine*
Cells can respond to DNA damage by activating checkpoints that delay cell cycle progression and allow time for DNA repair… 
2001
2001
G2 DNA Damage Checkpoint Inhibition and Antimitotic Activity of 13-Hydroxy-15-oxozoapatlin*
Checkpoints activated in response to DNA damage cause arrest in the G1 and G2 phases of the cell cycle. Inhibitors of the G2… 
1999
1999
An investigation of the G2 checkpoint
Current approaches to treating cancers often involve the use of drugs that are toxic to both cancer cells and normal cells. Over… 
1996
1996
Debromohymenialdisine and related compounds for the treatment of osteoarthritis
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