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cysteine-S-conjugate beta-lyase activity

Known as: L-cysteine-S-conjugate thiol-lyase (deaminating) activity, glutamine transaminase K/cysteine conjugate beta-lyase activity, cysteine-S-conjugate b-lyase activity 
Catalysis of the reaction: RS-CH2-CH(NH3+)COO- = RSH + NH3 + pyruvate. [EC:4.4.1.13, MetaCyc:CYSTEINE-S-CONJUGATE-BETA-LYASE-RXN]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1992
1992
High-performance liquid chromatography-fluorescence assay of pyruvic acid to determine cysteine conjugate beta-lyase activity: application to S-1,2-dichlorovinyl-L-cysteine and S-2-benzothiazolyl-L…
An HPLC-fluorescence assay has been developed for the determination of the activity of rat renal cytosolic cysteine conjugate… Expand
Highly Cited
1990
Highly Cited
1990
Purification and characterization of human kidney cytosolic cysteine conjugate beta-lyase activity.
The central role of cysteine conjugate beta-lyase (beta-lyase) in the bioactivation of nephrotoxic halogenated hydrocarbons and… Expand
1987
1987
Alpha-ketoacids stimulate rat renal cysteine conjugate beta-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine.
Renal cysteine conjugate beta-lyase (beta-lyase) catalyzes the bioactivation of nephrotoxic cysteine S-conjugates. beta-Lyase… Expand
1987
1987
Evidence for involvement of non-biliary excretion into the intestines in the formation of methylsulphonyl-containing metabolites of 2-chloro-N-isopropylacetanilide (propachlor) by swine and rats.
1. Radiolabelled metabolites excreted in the urine of swine after an oral dose of 14C-propachlor were similar to those previously… Expand
Highly Cited
1985
Highly Cited
1985
Isolation and characterization of a rat liver enzyme with both cysteine conjugate beta-lyase and kynureninase activity.
  • J. Stevens
  • The Journal of biological chemistry
  • 1985
    • Corpus ID: 30809410
Cysteine conjugate beta-lyase is a name applied to enzymes which cleave the S-cysteine conjugates of some xenobiotics to pyruvate… Expand
1985
1985
Cysteine conjugate beta-lyase activities in rat kidney cortex: subcellular localization and relationship to the hepatic enzyme.
  • J. Stevens
  • Biochemical and biophysical research…
  • 1985
    • Corpus ID: 12877456
Kidney cortex cysteine conjugate beta-lyase enzymes were characterized using S-(2-benzothiazolyl)-L-cysteine and S-(1,2… Expand
Highly Cited
1982
Highly Cited
1982
Assay of cysteine conjugate beta-lyase activity with S-(2-benzothiazolyl)cysteine as the substrate.
Cysteine conjugate β-lyases convert S-substituted cysteine conjugates to pyruvate, ammonia, and thiols. A simple assay for… Expand
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