cyclic nucleotide metabolic process

Known as: cyclic nucleotide metabolism 
The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions… (More)
National Institutes of Health

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1996
1996
Cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human detrusor smooth muscle. II. Effect of various PDE inhibitors on smooth muscle tone and cyclic nucleotide levels in vitro.
Phosphodiesterases (PDEs) regulate intracellular cyclic nucleotide metabolism and, thus, contraction and relaxation of smooth… (More)
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1996
1996
Cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human detrusor smooth muscle. I. Identification and characterization.
Phosphodiesterases (PDEs) are key enzymes involved in the regulation of intracellular cyclic nucleotide metabolism. The aim of… (More)
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Highly Cited
1989
Highly Cited
1989
Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness.
Reversible congestive heart failure can accompany cardiac allograft rejection and inflammatory myocarditis, conditions associated… (More)
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Highly Cited
1988
Highly Cited
1988
Effects of cilostazol, a selective cAMP phosphodiesterase inhibitor on the contraction of vascular smooth muscle.
The effects of cilostazol (OPC-13013, 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quin olinone) on cyclic… (More)
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Highly Cited
1986
Highly Cited
1986
Effects of new inotropic agents on cyclic nucleotide metabolism and calcium transients in canine ventricular muscle.
In isolated canine ventricular trabeculae and papillary muscles driven electrically at 0.5 Hz at 37 degrees C, the positive… (More)
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1984
1984
Effects of vinpocetine on cyclic nucleotide metabolism in vascular smooth muscle.
A novel vasodilating agent, vinpocetine (14-ethoxycarbonyl-(3 alpha,16 alpha-ethyl)-14,15-eburnamenine) inhibits Ca2+-dependent… (More)
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1982
1982
Positive inotropic effect of amrinone in relation to cyclic nucleotide metabolism in the canine ventricular muscle.
Experiments were carried out in the canine isolated right ventricular muscle in order to study the positive inotropic effect of… (More)
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1981
1981
Regulation of endothelial cell cyclic nucleotide metabolism by prostacyclin.
An analysis of prostaglandin-stimulated adenosine 3',5'-cyclic monophosphate (cyclic AMP) accumulation in cultured human… (More)
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1979
1979
Effect of purified Escherichia coli heat-stable enterotoxin on intestinal cyclic nucleotide metabolism and fluid secretion.
Enterotoxigenic Escherichia coli cause diarrhea by elaborating two enterotoxins. The large-molecular-weight, heat-labile toxin… (More)
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1976
1976
Calcium-dependent regulatory protein of cyclic nucleotide metabolism in normal and transformed chicken embryo fibroblasts.
The concentration of a calcium-binding protein modulator of 3':5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17; 3':5'-cyclic… (More)
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