Skip to search formSkip to main contentSkip to account menu

coumarin 7-hydroxylase activity

Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. [Reactome:163103]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1995
1995
Metabolism of coumarin by precision-cut calf liver slices and calf liver microsomes.
1. The metabolism of 50 microM [3-14C]coumarin has been studied in precision-cut-calf liver slices. 2. The metabolism of 50… 
1994
1994
Sex and strain differences in mouse hepatic microsomal coumarin 7-hydroxylase activity.
Highly Cited
1994
Highly Cited
1994
Human CYP2A6 activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK): mutational specificity in the gpt gene of AS52 cells.
The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone (NNK) is a potential human carcinogen that is… 
1993
1993
Cytochrome P4502A-mediated coumarin 7-hydroxylation and testosterone hydroxylation in mouse and rat lung.
Pulmonary coumarin 7-hydroxylase, testosterone hydroxylase and other P450-mediated activities were compared in the mouse and rat… 
1993
1993
Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases
SummaryAcute effects of a single intraperitoneal dose of allyl alcohol (AA, 64 mg/kg), dimethylnitrosamine (DMNA, 30 mg/kg… 
1992
1992
Peroxisome proliferators decrease coumarin 7-hydroxylase activity
1990
1990
Comparison of Mongolian gerbil and rat hepatic microsomal monooxygenase activities: high coumarin 7-hydroxylase activity in the gerbil.
Highly Cited
1988
Highly Cited
1988
Purification and characterization of a liver microsomal cytochrome P-450 isoenzyme with a high affinity and metabolic capacity for coumarin from pyrazole-treated D2 mice.
Microsomal coumarin 7-hydroxylase activity is regulated differently from several other monooxygenase enzymes, at least in mice… 
Highly Cited
1985
Highly Cited
1985
Selective induction of coumarin 7-hydroxylase by pyrazole in D2 mice.
Pyrazole, was given to DBA/2N (D2), C57BL/6N (B6) and AKR/N mice to study its effects on hepatic drug metabolism. A decrease in… 
1975
1975
High coumarin 7-hydroxylase activity does not protect mice against Warfarin
SummarySixteen strains of mice varied widely in their ability to 7-hydroxylate injected coumarin to form umbelliferone, which is… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)