Skip to search formSkip to main contentSkip to account menu

coumarin 7-hydroxylase activity

Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+. [Reactome:163103]
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2002
2002
Variation in coumarin 7-hydroxylase activity associated with genetic polymorphism of cytochrome P450 2A6 and the body status of iron stores in adult Thai males and females.
The relationships between catalytic activity of cytochrome P450 2A6 (CYP2A6), polymorphism of CYP2A6 gene, gender and levels of… 
1994
1994
Sex and strain differences in mouse hepatic microsomal coumarin 7-hydroxylase activity.
1993
1993
Cytochrome P4502A-mediated coumarin 7-hydroxylation and testosterone hydroxylation in mouse and rat lung.
Pulmonary coumarin 7-hydroxylase, testosterone hydroxylase and other P450-mediated activities were compared in the mouse and rat… 
1993
1993
Response of mouse liver coumarin 7-hydroxylase activity to hepatotoxins: dependence on strain and agent and comparison to other monooxygenases
SummaryAcute effects of a single intraperitoneal dose of allyl alcohol (AA, 64 mg/kg), dimethylnitrosamine (DMNA, 30 mg/kg… 
1992
1992
Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.
Coumarin 7-hydroxylase (P450coh) and steroid 15 alpha-hydroxylase (P450(15 alpha) are encoded by members within the mouse 2A… 
1992
1992
Peroxisome proliferators decrease coumarin 7-hydroxylase activity
1990
1990
Comparison of Mongolian gerbil and rat hepatic microsomal monooxygenase activities: high coumarin 7-hydroxylase activity in the gerbil.
Highly Cited
1988
Highly Cited
1988
Purification and characterization of a liver microsomal cytochrome P-450 isoenzyme with a high affinity and metabolic capacity for coumarin from pyrazole-treated D2 mice.
Microsomal coumarin 7-hydroxylase activity is regulated differently from several other monooxygenase enzymes, at least in mice… 
Highly Cited
1985
Highly Cited
1985
Selective induction of coumarin 7-hydroxylase by pyrazole in D2 mice.
Pyrazole, was given to DBA/2N (D2), C57BL/6N (B6) and AKR/N mice to study its effects on hepatic drug metabolism. A decrease in… 
1975
1975
High coumarin 7-hydroxylase activity does not protect mice against Warfarin
SummarySixteen strains of mice varied widely in their ability to 7-hydroxylate injected coumarin to form umbelliferone, which is… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)