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Hepatotoxicity of coumarin is attributed to metabolic activation to an epoxide intermediate, coumarin 3,4-epoxide (CE). However… Expand Coumarin-induced mouse Clara cell toxicity is thought to result from the local formation of coumarin 3,4-epoxide (CE). However… Expand Species differences in the biotransformation of coumarin are thought to play an important role in its toxicity. Since the… Expand Coumarin, a widely used fragrance ingredient, is a rat liver and mouse lung toxicant. Species differences in toxicity are… Expand Coumarin was identified as a mouse-lung carcinogen following oral gavage administration in a chronic bioassay, and was shown to… Expand Coumarin is used widely as a fragrance constituent and is administered clinically in the treatment of certain lymphedemas and… Expand The mechanism of acute coumarin-induced hepatotoxicity in the rat has been investigated by comparing the effects of coumarin with… Expand 1. Investigations of coumarin metabolism and hepatotoxicity have been reviewed. 2. Species differences in coumarin hepatotoxicity… Expand A coumarin mercapturic acid, N-acetyl-S-(3-coumarinyl)cysteine, has been identified in the urine of coumarin-treated rats. [14C… Expand Single doses of coumarin (125 mg/kg, ip) produced a depletion of hepatic nonprotein sulfhydryl groups (mainly reduced glutathione… Expand