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coumarin 3,4-epoxide

National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
Hepatotoxicity of coumarin is attributed to metabolic activation to an epoxide intermediate, coumarin 3,4-epoxide (CE). However… Expand
2004
2004
Coumarin-induced mouse Clara cell toxicity is thought to result from the local formation of coumarin 3,4-epoxide (CE). However… Expand
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2003
2003
Species differences in the biotransformation of coumarin are thought to play an important role in its toxicity. Since the… Expand
Highly Cited
2002
Highly Cited
2002
Coumarin, a widely used fragrance ingredient, is a rat liver and mouse lung toxicant. Species differences in toxicity are… Expand
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1999
1999
Coumarin was identified as a mouse-lung carcinogen following oral gavage administration in a chronic bioassay, and was shown to… Expand
Highly Cited
1997
Highly Cited
1997
Coumarin is used widely as a fragrance constituent and is administered clinically in the treatment of certain lymphedemas and… Expand
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1994
1994
The mechanism of acute coumarin-induced hepatotoxicity in the rat has been investigated by comparing the effects of coumarin with… Expand
Review
1993
Review
1993
  • J. Fentem, J. Fry
  • Comparative biochemistry and physiology. C…
  • 1993
  • Corpus ID: 21243406
1. Investigations of coumarin metabolism and hepatotoxicity have been reviewed. 2. Species differences in coumarin hepatotoxicity… Expand
1991
1991
A coumarin mercapturic acid, N-acetyl-S-(3-coumarinyl)cysteine, has been identified in the urine of coumarin-treated rats. [14C… Expand
Highly Cited
1989
Highly Cited
1989
Single doses of coumarin (125 mg/kg, ip) produced a depletion of hepatic nonprotein sulfhydryl groups (mainly reduced glutathione… Expand