cotransin
National Institutes of Health
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ABSTRACT A new cyclic decadepsipeptide was isolated from Chaetosphaeria tulasneorum with potent bioactivity on mammalian and…
Protein translocation into the endoplasmic reticulum (ER) constitutes the first step of protein secretion. ER protein import is…
The cyclodepsipeptide cotransin was described to inhibit the biosynthesis of a small subset of proteins by a signal sequence…
Membrane protein biogenesis requires the coordinated movement of hydrophobic transmembrane domains (TMD) from the cytosolic…
The specific inhibition of the biosynthesis of target proteins is a relatively novel strategy in pharmacology and is based mainly…
The first solid-phase synthesis of cotransin--a cyclic depsipeptide having high pharmacological potential--was achieved, by a…
The segregation of secretory and membrane proteins to the mammalian endoplasmic reticulum is mediated by remarkably diverse…