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cotransin

 
National Institutes of Health

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Cyclic Peptides

Papers overview

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2016
2016
Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel.
Apratoxin A is a cytotoxic natural product that prevents the biogenesis of secretory and membrane proteins. Biochemically… Expand
Review
2015
Review
2015
Inhibitors of Protein Translocation Across the ER Membrane
Protein translocation into the endoplasmic reticulum (ER) constitutes the first step of protein secretion. ER protein import is… Expand
2015
2015
Decatransin, a new natural product inhibiting protein translocation at the Sec61/SecYEG translocon
ABSTRACT A new cyclic decadepsipeptide was isolated from Chaetosphaeria tulasneorum with potent bioactivity on mammalian and… Expand
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2015
2015
Defining a Conformational Consensus Motif in Cotransin-Sensitive Signal Sequences: A Proteomic and Site-Directed Mutagenesis Study
The cyclodepsipeptide cotransin was described to inhibit the biosynthesis of a small subset of proteins by a signal sequence… Expand
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Highly Cited
2014
Highly Cited
2014
An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate
Membrane protein biogenesis requires the coordinated movement of hydrophobic transmembrane domains (TMD) from the cytosolic… Expand
2013
2013
Cotransin induces accumulation of a cytotoxic clusterin variant that cotranslationally rerouted to the cytosol.
Although clusterin (CLU) was originally identified as a secreted glycoprotein that plays cytoprotective role, several… Expand
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2011
2011
Inhibition of Biosynthesis of Human Endothelin B Receptor by the Cyclodepsipeptide Cotransin*
The specific inhibition of the biosynthesis of target proteins is a relatively novel strategy in pharmacology and is based mainly… Expand
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2011
2011
Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators.
Cotransins are cyclic heptadepsipeptides that bind the Sec61 translocon to inhibit cotranslational translocation of a subset of… Expand
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2008
2008
Solid-phase synthesis of a cyclodepsipeptide: cotransin.
The first solid-phase synthesis of cotransin--a cyclic depsipeptide having high pharmacological potential--was achieved, by a… Expand
Highly Cited
2005
Highly Cited
2005
A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum
The segregation of secretory and membrane proteins to the mammalian endoplasmic reticulum is mediated by remarkably diverse… Expand
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