cotransin
National Institutes of Health
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Secreted and membrane proteins play key roles in malignant transformation and tumor growth, including autocrine growth factor…
Protein translocation into the endoplasmic reticulum (ER) constitutes the first step of protein secretion. ER protein import is…
The cyclodepsipeptide cotransin was described to inhibit the biosynthesis of a small subset of proteins by a signal sequence…
The specific inhibition of the biosynthesis of target proteins is a relatively novel strategy in pharmacology and is based mainly…
Author(s): MacKinnon, Andrew L. | Advisor(s): Taunton, Jack | Abstract: Cotransins are a class of cyclic-heptadepsi-peptides that…
The first solid-phase synthesis of cotransin--a cyclic depsipeptide having high pharmacological potential--was achieved, by a…
Secreted and transmembrane proteins represent the majority of current drug targets and play a dominant role in pathophysiological…