cotransin

Apratoxin A is a cytotoxic natural product that prevents the biogenesis of secretory and membrane proteins. Biochemically… (More)

The cyclodepsipeptide cotransin was described to inhibit the biosynthesis of a small subset of proteins by a signal sequence… (More)

A new cyclic decadepsipeptide was isolated from Chaetosphaeria tulasneorum with potent bioactivity on mammalian and yeast cells… (More)

Membrane protein biogenesis requires the coordinated movement of hydrophobic transmembrane domains (TMD) from the cytosolic… (More)

The specific inhibition of the biosynthesis of target proteins is a relatively novel strategy in pharmacology and is based mainly… (More)

Cotransins are cyclic heptadepsipeptides that bind the Sec61 translocon to inhibit cotranslational translocation of a subset of… (More)

The first solid-phase synthesis of cotransin--a cyclic depsipeptide having high pharmacological potential--was achieved, by a… (More)

The segregation of secretory and membrane proteins to the mammalian endoplasmic reticulum is mediated by remarkably diverse… (More)