cortistatin A
National Institutes of Health
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INTRODUCTION
The regulation of apoptosis via compounds originated from marine organisms signifies a new wave in the field of drug…
“Our results highlight an alternative approach to current anti-HIV strategies,” said Susana Valente, a TSRI associate professor…
Infection by HIV-1 can effectively be suppressed by antiretroviral therapy (ART). However, the persistence of a small, latent…
Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were…
Angiogenesis, the formation of new blood capillaries from preexisting blood vessels, is a vital process in growth of solid tumors…
: Angiogenesis, the formation of new blood capillaries from preexisting blood vessels, is a vital process in growth of solid…
Syntheses of structurally simplified analogues of cortistatin A (1), a novel antiangiogenic steroidal alkaloid from Indonesian…
A stereoselective synthesis of the core structure of cortistatin A (1), a novel antiangiogenic steroidal alkaloid from Indonesian…
Biologically active natural products often contain interesting and complex structural features and functionalities that make them…
Full details are provided for an improved synthesis of cortistatin A and related structures as well as the underlying logic and…