cortistatin A

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2017
012320062017

Papers overview

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2016
2016
Cortistatin A (CA) is a highly selective inhibitor of the Mediator kinases CDK8 and CDK19. Using CA, we now report a large-scale… (More)
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2015
2015
Super-enhancers (SEs), which are composed of large clusters of enhancers densely loaded with the Mediator complex, transcription… (More)
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2012
2012
The human immunodeficiency virus type 1 (HIV) Tat protein, a potent activator of HIV gene expression, is essential for integrated… (More)
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2011
2011
Full details are provided for an improved synthesis of cortistatin A and related structures as well as the underlying logic and… (More)
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2011
2011
We describe herein the synthesis of a late-stage intermediate en route to cortistatin A. Key transformations included a Snieckus… (More)
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2009
2009
show potent and selective antiproliferative properties against human umbilical vein endothelial cells (HUVECs) spurred a surge of… (More)
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2008
2008
Cortistatin A is a marine steroid with highly selective and perhaps mechanistically unique antiangiogenic activity. Herein we… (More)
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2008
2008
Angiogenesis is an important physiological phenomenon whose imbalance may result in several disease states, including malignant… (More)
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2007
2007
Previously, bioassay-guided separation led us to isolate eleven novel steroidal alkaloids named cortistatins from the marine… (More)
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2006
2006
Four novel steroidal alkaloids named cortistatins A (1), B (2), C (3), and D (4) consisting of a 9(10-19)-abeo-androstane and… (More)
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