contryphan

A new member of the contryphans family was isolated from the venom of Conus betilinus, a vermivorous species distributed in the… (More)

Grafting bioactive peptide sequences onto small cysteine-rich scaffolds is a promising strategy for enhancing their stability and… (More)

The fragmentation of positive and negative ions of peptide disulfides under mass spectrometric conditions yields distinctly… (More)

Stabilization of biologically active peptides is a major goal in peptide-based drug design. Cyclization is an often-used strategy… (More)

The solution structure of contryphan-Vn, a cyclic peptide with a double cysteine S-S bridge and containing a D-tryptophan… (More)

Contryphans constitute a group of conopeptides that are known to contain an unusual density of post-translational modifications… (More)

Glacontryphan-M, a novel calcium-dependent inhibitor of L-type voltage-gated Ca(2+) channels expressed in mouse pancreatic beta… (More)

The contryphan family of cyclic peptides, isolated recently from various species of cone shell, has the conserved sequence motif… (More)

Contryphan-R, from venom of the cone-shell Conus radiatus, represents a novel cyclic peptide scaffold onto which residues may be… (More)

In this report, we document for the first time the occurrence of D-tryptophan in a normally translated polypeptide, contryphan… (More)