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Gene targeting by homologous recombination (HR) can be induced by double-strand breaks (DSBs), however these breaks can be toxic… Expand We developed a method for simply and rapidly detecting cofactors of aptazymes with high sensitivity using unique noncrosslinking… Expand The Invader assay uses a structure-specific flap endonuclease (FEN) to cleave a three-dimensional complex formed by hybridization… Expand The CFLP methodology was applied for Cleavase I site detection within ptDNA intergenic regions (atpB-rbcL and rps14-psaB) at both… Expand The removal of impurities and contaminants from PCR‐amplified fragments is important for mutation detection methods which… Expand Cleavase® fragment length polymorphism (CFLP) is a newly developed method used for the detection of gene mutation. This study… Expand Background: Congenital adrenal hyperplasia (CAH) owing to steroid 21-hydroxylase deficiency results from mutations in CYP21. The… Expand Background: Genetic screening requires methods for mutation detection that are sensitive, precise, and robust. In population… Expand We describe the application of a new DNA-scanning method, which has been termed Cleavase Fragment Length Polymorphism (CFLP… Expand We describe here a new approach for analyzing nucleic acid sequences using a structure-specific endonuclease, Cleavase I. We have… Expand