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cis-Urocanic Acid

Known as: cis-UCA 
A derivative of the amino acid histidine, formed in the mammalian skin from trans-urocanic acid upon ultraviolet radiation, and protodynamic agent… 
National Institutes of Health

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Related topics

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NCIt Antineoplastic Agent Terminology

Papers overview

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2009
2009
Cis-urocanic acid suppresses UV-B-induced interleukin-6 and -8 secretion and cytotoxicity in human corneal and conjunctival epithelial cells in vitro
Purpose Urocanic acid (UCA) is a major ultraviolet (UV)-absorbing endogenous chromophore in the epidermis and is also an… 
2000
2000
Lack of metallothionein‐I and ‐II exacerbates the immunosuppressive effect of ultraviolet B radiation and cis‐urocanic acid in mice
The effect of a null mutation for the metallothionein (MT)‐I and ‐II isoforms in mice on the immunosuppressive action of… 
Highly Cited
1999
Highly Cited
1999
Heme oxygenase induction mediates the photoimmunoprotective activity of UVA radiation in the mouse.
In contrast to the immunosuppressive potential of UVB (280-320 nm) radiation in experimental animals and humans, UVA (320-400 nm… 
Highly Cited
1997
Highly Cited
1997
Histamine involvement in UVB‐ and cis‐urocanic acid‐induced systemic suppression of contact hypersensitivity responses
Studies in experimental models have implicated histamine and prostanoids in ultra‐violet B (UVB)‐ and cis‐urocanic acid (UCA… 
Highly Cited
1995
Highly Cited
1995
Cis‐UROCANIC ACID SYNERGIZES WITH HISTAMINE FOR INCREASED PGE2 PRODUCTION BY HUMAN KERATINOCYTES: LINK TO INDOMETHACIN‐INHIBITABLE UVB‐INDUCED IMMUNOSUPPRESSION
Abstract— There is considerable evidence that suppression of the immune system by UVB (280–320 nm UV) irradiation is initiated by… 
Highly Cited
1993
Highly Cited
1993
ACTION SPECTRA FOR THE trans TO cis PHOTOISOMERISATION OF UROCANIC ACID in vitro and IN MOUSE SKIN
Urocanic acid (UCA) is a major UV chromophore in the upper layers of the skin where it is found predominantly as the trans isomer… 
1992
1992
Cis‐UROCANIC ACID DOWN‐REGULATES THE INDUCTION OF ADENOSINE 3', 5'‐CYCLIC MONOPHOSPHATE BY EITHER trans‐UROCANIC ACID OR HISTAMINE IN HUMAN DERMAL FIBROBLASTS in vitro
Abstract— It has been demonstrated that UVB radiation (290–320 nm) suppresses mammalian cell‐mediated immunity by effecting the… 
Highly Cited
1990
Highly Cited
1990
The effect of histamine receptor antagonists on immunosuppression induced by the cis-isomer of urocanic acid.
Urocanic acid (UCA) is found in the stratum corneum predominantly as the trans-isomer; on ultraviolet B (UVB) irradiation… 
Highly Cited
1989
Highly Cited
1989
UROCANIC ACID ANALOGUES AND THE SUPPRESSION OF THE DELAYED TYPE HYPERSENSITIVITY RESPONSE TO Herpes simplex VIRUS
Abstract 
1988
1988
Suppression of contact hypersensitivity by short-term ultraviolet irradiation: II. The role of urocanic acid.
Cis-urocanic acid (cis-UCA), produced from trans-UCA (a normal component of epidermis) by UV irradiation, suppressed cell… 
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