cholesterol-5,6-oxide hydrolase activity

Known as: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity, ChEH, cholesterol-epoxide hydrolase activity 
Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2017
02419862017

Papers overview

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2017
2017
5,6α-epoxycholesterol (5,6α-EC) and 5,6β-epoxycholesterol (5,6β-EC) are oxysterols involved in the anticancer pharmacology of the… (More)
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2015
2015
BACKGROUND Tamoxifen (TAM) is an important cancer therapeutic and an experimental tool for effecting genetic recombination using… (More)
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2013
2013
Tamoxifen (Tam) is a selective estrogen receptor modulator (SERM) that remains one of the major drugs used in the hormonotherapy… (More)
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Review
2013
Review
2013
In the nineteen sixties it was proposed that cholesterol might be involved in the etiology of cancers and cholesterol oxidation… (More)
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2012
2012
We recently established that drugs used for the treatment and the prophylaxis of breast cancers, such as tamoxifen, were potent… (More)
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Review
2012
Review
2012
Cholesterol epoxide hydrolase (ChEH) catalyzes the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3β,5α,6β-triol… (More)
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2010
2010
The microsomal antiestrogen binding site (AEBS) is a high-affinity target for the antitumor drug tamoxifen and its cognate… (More)
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2004
2004
 
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2004
2004
1. Nach Injektion hoher Dosen von Cholinesterase-Hemmern (ChEH) findet man im Gehirn von Mäusen ungebundenen Hemmstoff. Freies… (More)
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1986
1986
Hepatic cholesterol-epoxide hydrolase is a microsomal enzyme which appears to be catalytically distinct from the epoxide… (More)
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