Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

cholesterol-5,6-oxide hydrolase activity

Known as: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity, ChEH, cholesterol-epoxide hydrolase activity 
Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Significance Cholesterol and its transformation into cholesterol-5,6-epoxides (5,6-EC) was long suspected as contributing to… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2016
2016
RESULTS We confirmed previously observed significant associations between coronary artery disease and low-frequency missense… Expand
  • table 1
  • table 2
  • table 3
  • figure 1
  • figure 2
Is this relevant?
Review
2016
Review
2016
Tamoxifen (Tam) was developed as a ligand and modulator of estrogen receptor α (ERα) and is one of the main drugs used globally… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2015
2015
BackgroundTamoxifen (TAM) is an important cancer therapeutic and an experimental tool for effecting genetic recombination using… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2013
2013
Tamoxifen (Tam) is a selective estrogen receptor modulator (SERM) that remains one of the major drugs used in the hormonotherapy… Expand
Is this relevant?
Review
2012
Review
2012
Cholesterol epoxide hydrolase (ChEH) catalyzes the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3β,5α,6β-triol… Expand
  • figure 1
  • figure 2
  • table 1
  • table 2
Is this relevant?
Highly Cited
2010
Highly Cited
2010
The microsomal antiestrogen binding site (AEBS) is a high-affinity target for the antitumor drug tamoxifen and its cognate… Expand
  • figure 2
  • figure 1
  • table 1
  • figure 4
  • figure 3
Is this relevant?
2010
2010
The renal outer medullary K(+) (ROMK) channel plays a critical role in renal sodium handling. Recent genome sequencing efforts in… Expand
Is this relevant?
Highly Cited
2009
Highly Cited
2009
OBJECTIVES QT interval prolongation is associated with increased risk of sudden cardiac death at the population level. As 30-40… Expand
  • table 1
  • table 2
  • table 3
Is this relevant?
2002
2002
Expatriate volunteers in Phnom Penh, Cambodia, work in a country where many of their fellow expatriates are paid considerably… Expand
Is this relevant?