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cholesterol-5,6-oxide hydrolase activity

Known as: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity, ChEH, cholesterol-epoxide hydrolase activity 
Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor
Significance Cholesterol and its transformation into cholesterol-5,6-epoxides (5,6-EC) was long suspected as contributing to… Expand
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2016
2016
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease.
RESULTS We confirmed previously observed significant associations between coronary artery disease and low-frequency missense… Expand
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Review
2016
Review
2016
From tamoxifen to dendrogenin A: The discovery of a mammalian tumor suppressor and cholesterol metabolite.
Tamoxifen (Tam) was developed as a ligand and modulator of estrogen receptor α (ERα) and is one of the main drugs used globally… Expand
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2015
2015
Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis
BackgroundTamoxifen (TAM) is an important cancer therapeutic and an experimental tool for effecting genetic recombination using… Expand
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2013
2013
5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of tamoxifen in breast cancer cells.
Tamoxifen (Tam) is a selective estrogen receptor modulator (SERM) that remains one of the major drugs used in the hormonotherapy… Expand
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Review
2012
Review
2012
Cholesterol epoxide hydrolase and cancer.
Cholesterol epoxide hydrolase (ChEH) catalyzes the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3β,5α,6β-triol… Expand
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Highly Cited
2010
Highly Cited
2010
Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands
The microsomal antiestrogen binding site (AEBS) is a high-affinity target for the antitumor drug tamoxifen and its cognate… Expand
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2010
2010
Hypertension resistance polymorphisms in ROMK (Kir1.1) alter channel function by different mechanisms.
The renal outer medullary K(+) (ROMK) channel plays a critical role in renal sodium handling. Recent genome sequencing efforts in… Expand
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Highly Cited
2009
Highly Cited
2009
Common candidate gene variants are associated with QT interval duration in the general population.
OBJECTIVES QT interval prolongation is associated with increased risk of sudden cardiac death at the population level. As 30-40… Expand
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2002
2002
Should they be committed? Motivating volunteers in Phnom Penh, Cambodia
Expatriate volunteers in Phnom Penh, Cambodia, work in a country where many of their fellow expatriates are paid considerably… Expand
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