FAQ

cholesterol-5,6-oxide hydrolase activity

Known as: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol hydrolase activity, ChEH, cholesterol-epoxide hydrolase activity 
Catalysis of the reactions: 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = cholestane-3beta-5alpha,6beta-triol, and 5,6beta-epoxy-5beta-cholestan… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2017
02419862017

Papers overview

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2017
2017
Improvement of 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, cholestane-3β,5α,6β-triol and 6-oxo-cholestan-3β,5α-diol recovery for quantification by GC/MS.
5,6α-epoxycholesterol (5,6α-EC) and 5,6β-epoxycholesterol (5,6β-EC) are oxysterols involved in the anticancer pharmacology of the… (More)
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2015
2015
Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis
BACKGROUND Tamoxifen (TAM) is an important cancer therapeutic and an experimental tool for effecting genetic recombination using… (More)
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2013
2013
5,6-Epoxy-cholesterols contribute to the anticancer pharmacology of tamoxifen in breast cancer cells.
Tamoxifen (Tam) is a selective estrogen receptor modulator (SERM) that remains one of the major drugs used in the hormonotherapy… (More)
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Review
2013
Review
2013
Cholesterol-5,6-epoxides: chemistry, biochemistry, metabolic fate and cancer.
In the nineteen sixties it was proposed that cholesterol might be involved in the etiology of cancers and cholesterol oxidation… (More)
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2012
2012
Surprising unreactivity of cholesterol-5,6-epoxides towards nucleophiles.
We recently established that drugs used for the treatment and the prophylaxis of breast cancers, such as tamoxifen, were potent… (More)
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Review
2012
Review
2012
Cholesterol epoxide hydrolase and cancer.
Cholesterol epoxide hydrolase (ChEH) catalyzes the hydration of cholesterol-5,6-epoxides (5,6-EC) into cholestane-3β,5α,6β-triol… (More)
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2010
2010
Identification and pharmacological characterization of cholesterol-5,6-epoxide hydrolase as a target for tamoxifen and AEBS ligands.
The microsomal antiestrogen binding site (AEBS) is a high-affinity target for the antitumor drug tamoxifen and its cognate… (More)
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2004
2004
Vergleich zwischen der Wirksamkeit von Cholinesterasehemmern in vitro und in vivo
 
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2004
2004
Inaktivierung von Alkylphosphaten im Gehirn und im Serum
1. Nach Injektion hoher Dosen von Cholinesterase-Hemmern (ChEH) findet man im Gehirn von Mäusen ungebundenen Hemmstoff. Freies… (More)
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1986
1986
Catalytic properties and inhibition of hepatic cholesterol-epoxide hydrolase.
Hepatic cholesterol-epoxide hydrolase is a microsomal enzyme which appears to be catalytically distinct from the epoxide… (More)
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