chivosazole F
National Institutes of Health
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The microbial metabolite Chivosazole F has been described to affect the cytoskeleton and to inhibit actin polymerization in vitro…
Abstract A unified strategy for the chemical synthesis of the chivosazoles is described. This strategy is based on two closely…
The first synthesis of the highly biologically active chivosazole F is described. It features an intramolecular Stille coupling…
An advanced C15-C35 subunit of the chivosazole polyene macrolides was prepared in a convergent manner, exploiting boron-mediated…
암세포가 특정 항암제에 의해 내성을 획득하면 구조가 상이한 타 항암제에도 교차내성을 나타내는 이른바 암세포의 다약제내성(MDR…