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chemical conjugate

National Institutes of Health

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2 relations

Broader (1)

chemical aggregate

Narrower (1)

conjugated polyene

Papers overview

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2019
2019
A chemical conjugate between HER2-targeting antibody fragment and Pseudomonas exotoxin A fragment demonstrates cytotoxic effects on HER2-expressing breast cancer cells
Conventionally, immunotoxins have been produced as a single polypeptide from fused genes of an antibody fragment and a toxin. In… 
2015
2015
A Stable Chemical SUMO1–Ubc9 Conjugate Specifically Binds as a Thioester Mimic to the RanBP2–E3 Ligase Complex
Ubiquitin and ubiquitin‐like (Ubl) modifiers such as SUMO are conjugated to substrate proteins by E1, E2, and E3 enzymes. In the… 
2009
2009
The melanoma specific 9.2.27PE immunotoxin efficiently kills melanoma cells in vitro
Malignant melanomas are generally drug resistant and have a very poor prognosis. We have studied the effects of a chemical… 
Highly Cited
2006
Highly Cited
2006
Oral delivery of chemical conjugates of heparin and deoxycholic acid in aqueous formulation.
Highly Cited
2006
Highly Cited
2006
Efficacy of orally active chemical conjugate of low molecular weight heparin and deoxycholic acid in rats, mice and monkeys.
1999
1999
An antigenic HIV‐1 peptide sequence engineered into the surface structure of transferrin does not elicit an antibody response
1998
1998
Intracerebral bispecific ligand‐antibody conjugate increases survival of animals bearing endogenously arising brain tumors
Bispecific antibodies capable of simultaneously binding a tumor surface antigen and the T‐cell receptor/CD3 complex are capable… 
1995
1995
Saporin toxins directed to basic fibroblast growth factor receptors effectively target human ovarian teratocarcinoma in an animal model
Background. The antitumor activity of the chemical conjugate and recombinant forms of the mitotoxin basic fibroblast growth… 
Highly Cited
1993
Highly Cited
1993
BR96 sFv-PE40, a potent single-chain immunotoxin that selectively kills carcinoma cells.
We have constructed a single-chain immunotoxin composed of the carcinoma-reactive antibody BR96 and a truncated form of… 
1985
1985
Suppression of IgE antibody response against ovalbumin by the chemical conjugate of ovalbumin with a polyaspartic acid derivative.
Ovalbumin was modified with alpha,beta-poly[(2-hydroxyethyl)-DL-aspartamide] which had been developed as a nontoxic plasma… 
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