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chaetocin

National Institutes of Health

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Piperazines

Papers overview

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2017
2017
Chaetocin enhances dendritic cell function via the induction of heat shock protein and cancer testis antigens in myeloma cells
Dendritic cells (DC)-based vaccines are considered useful in cancer immuno-therapy, and the interactions of DC and dying tumor… 
2016
2016
Effect of chaetocin on renal cell carcinoma cells and cytokine-induced killer cells
We examined the cytotoxic effects of chaetocin on clear cell renal cell carcinoma (ccRCC) cells and the possibility to combine… 
2015
2015
Low expression of endothelin receptor B (EDNRB) is related to H3K9me3 binding with the EDNRB promoter region and is associated with the clinical T tumor stage in salivary adenoid cystic carcinoma.
2015
2015
Inhibition of H3K9 methyltransferase as a potent therapeutic target in multiple myeloma
2014
2014
Non‐radioactive Protein Lysine Methyltransferase Microplate Assay Based on Reading Domains
New protein lysine methyltransferase (PKMT) assays are needed to facilitate screening for improved PKMT inhibitors, because PKMTs… 
2013
2013
Identification and Characterization of the Spodoptera Su(var) 3-9 Histone H3K9 trimethyltransferase and Its Effect in AcMNPV Infection
Histone H3-lysine9 (H3K9) trimethyltransferase gene Su(var) 3-9 was cloned and identified in three Spodoptera insects, Spodoptera… 
2012
2012
gene promoter is epigenetically silenced by CTIP 2 and SUV 39 H 1
Mainly regulated at the transcriptional level, the cellular cyclin-dependent kinase inhibitor, CDKN1A/p21WAF1 (p21), is a major… 
2011
2011
On the determination of the stereochemistry of semisynthetic natural product analogues using chiroptical spectroscopy: desulfurization of epidithiodioxopiperazine fungal metabolites.
Isolation and semisynthetic modification of the fungal metabolite chaetocin gave access to a desulfurized analogue of this… 
2010
2010
Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation.
2007
2007
Chaetocin, a promising new anti-myeloma agent with in vitro and in vivo activity linked to oxidative stress
1535 Chaetocin, a thiodioxopiperazine natural product previously unreported to have anti-cancer effects, was found to have potent… 
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