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cefoselis

Known as: (-)-5-Amino-2-(((6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-(2-hydroxyethyl)pyrazolium hydroxide, inner salt, 7(sup 2)-(Z)-(O-methyloxime), 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-, (6R-(6alpha,7beta(Z)))-, sulfate (salt) (1:1) 
A semisynthetic, broad-spectrum, beta-lactamase-resistant, fourth-generation cephalosporin with antibacterial activity. Cefoselis binds to and… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Anti-Bacterial AgentsCeftizoxime

Narrower (1)

FK 037
analogs & derivatives

Papers overview

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2011
2011
A multicenter study on the in vitro antibacterial activity of cefoselis against common clinical bacteria
Objective To evaluate the in vitro antibacterial activity of cefoselis against common clinical bacteria,including gram-positive… 
2004
2004
Cefoselis, a β-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release
Summary.Cefoselis is a widely used β-lactam antibiotic, but occasionally induces seizures and convulsion in elder and renal… 
Highly Cited
2002
Highly Cited
2002
Antimicrobial susceptibility of major pathogens of orofacial odontogenic infections to 11 beta-lactam antibiotics.
In this study, we evaluated the current effectiveness of 11 beta-lactam antibiotics for treatment of orofacial odontogenic… 
2002
2002
The β-lactam antibiotics,penicillin-G and cefoselis have different mechanisms and sites of action at GABAA receptors
2001
2001
Effect of experimental renal failure on the pharmacodynamics of cefoselis-induced seizures in rats.
We investigated the effect of infusion rate and experimental renal failure on the pharmacodynamics of cefoselis (CFSL)-induced… 
2000
2000
Synthesis and structure-activity relationships of quaternary ammonium cephalosporins with 3-pyrazolylpyridinium derivatives.
2000
2000
[Clinical effects of cefoselis (CFSL) on infections in obstetric and gynecologic field and prevention of postoperative infections].
Clinical effects of cefoselis (CFSL) on various infections and prevention of postoperative infections in the field of obstetrics… 
2000
2000
In-vitro activity of FK 037 (Cefoselis), a novel 4(th) generation cephalosporin, compared to cefepime and cefpirome on nosocomial staphylococci and gram-negative isolates.
1999
1999
Role of Inhibition of Penicillin Binding Proteins and Cell Wall Cross-Linking by Beta-Lactam Antibiotics in Low- and High-Level Methicillin Resistance of Staphylococcus aureus
We have investigated the relationships between the minimum inhibitory concentrations (MICs) of eight β-lactams and their binding… 
Review
1996
Review
1996
Tissue penetration of the fourth generation parenteral cephalosporins.
In this review, the methods employed to study tissue penetration are discussed. Mathematical, animal and human models all have… 
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