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cefoselis

Known as: (-)-5-Amino-2-(((6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-(2-hydroxyethyl)pyrazolium hydroxide, inner salt, 7(sup 2)-(Z)-(O-methyloxime), 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-, (6R-(6alpha,7beta(Z)))-, sulfate (salt) (1:1) 
A semisynthetic, broad-spectrum, beta-lactamase-resistant, fourth-generation cephalosporin with antibacterial activity. Cefoselis binds to and… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Anti-Bacterial AgentsCeftizoxime

Narrower (1)

FK 037
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1.
2004
2004
Cefoselis, a β-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release
Summary.Cefoselis is a widely used β-lactam antibiotic, but occasionally induces seizures and convulsion in elder and renal… 
Highly Cited
2003
Highly Cited
2003
Evidence for the involvement of GABAA receptor blockade in convulsions induced by cephalosporins
2002
2002
The beta-lactam antibiotics, penicillin-G and cefoselis have different mechanisms and sites of action at GABA(A) receptors.
The action of the beta-lactam antibiotics, penicillin-G (PCG) and cefoselis (CFSL) on GABA(A) receptors (GABA(A)-R) was… 
Highly Cited
2002
Highly Cited
2002
Antimicrobial susceptibility of major pathogens of orofacial odontogenic infections to 11 beta-lactam antibiotics.
In this study, we evaluated the current effectiveness of 11 beta-lactam antibiotics for treatment of orofacial odontogenic… 
2001
2001
Effect of experimental renal failure on the pharmacodynamics of cefoselis-induced seizures in rats.
We investigated the effect of infusion rate and experimental renal failure on the pharmacodynamics of cefoselis (CFSL)-induced… 
Highly Cited
2000
Highly Cited
2000
β-Lactam Antibiotics as Substrates for OCTN2, an Organic Cation/Carnitine Transporter*
Therapeutic use of cephaloridine, a β-lactam antibiotic, in humans is associated with carnitine deficiency. A potential mechanism… 
2000
2000
Synthesis and structure-activity relationships of quaternary ammonium cephalosporins with 3-pyrazolylpyridinium derivatives.
Review
1997
Review
1997
Cefpirome. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy in the treatment of severe nosocomial infections and febrile neutropenia.
Cefpirome is an injectable extended-spectrum or 'fourth generation' cephalosporin. Its antibacterial activity encompasses many of… 
Highly Cited
1996
Highly Cited
1996
Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa
Various Pseudomonas aeruginosa PAO1 NfxB mutants were isolated on agar plates containing cefpirome and ofloxacin. They were… 
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