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cefoselis
Known as:
(-)-5-Amino-2-(((6R,7R)-7-(2-(2-amino-4-thiazolyl)glyoxylamido)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-(2-hydroxyethyl)pyrazolium hydroxide, inner salt, 7(sup 2)-(Z)-(O-methyloxime)
, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((2,3-dihydro-2-(2-hydroxyethyl)-3-imino-1H-pyrazol-1-yl)methyl)-8-oxo-, (6R-(6alpha,7beta(Z)))-, sulfate (salt) (1:1)
A semisynthetic, broad-spectrum, beta-lactamase-resistant, fourth-generation cephalosporin with antibacterial activity. Cefoselis binds to and…
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National Institutes of Health
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Related topics
Related topics
4 relations
Broader (2)
Anti-Bacterial Agents
Ceftizoxime
Narrower (1)
FK 037
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1.
Harumasa Ueo
,
H. Motohashi
,
T. Katsura
,
K. Inui
Biochemical pharmacology
2005
Corpus ID: 23783990
2004
2004
Cefoselis, a β-lactam antibiotic, easily penetrates the blood-brain barrier and causes seizure independently by glutamate release
K. Ohtaki
,
K. Matsubara
,
+6 authors
H. Shiono
Journal of Neural Transmission
2004
Corpus ID: 13043812
Summary.Cefoselis is a widely used β-lactam antibiotic, but occasionally induces seizures and convulsion in elder and renal…
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Highly Cited
2003
Highly Cited
2003
Evidence for the involvement of GABAA receptor blockade in convulsions induced by cephalosporins
M. Sugimoto
,
I. Uchida
,
+6 authors
N. Matsuoka
Neuropharmacology
2003
Corpus ID: 28570935
2002
2002
The beta-lactam antibiotics, penicillin-G and cefoselis have different mechanisms and sites of action at GABA(A) receptors.
M. Sugimoto
,
S. Fukami
,
+4 authors
T. Mashimo
British journal of pharmacology
2002
Corpus ID: 38140504
The action of the beta-lactam antibiotics, penicillin-G (PCG) and cefoselis (CFSL) on GABA(A) receptors (GABA(A)-R) was…
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Highly Cited
2002
Highly Cited
2002
Antimicrobial susceptibility of major pathogens of orofacial odontogenic infections to 11 beta-lactam antibiotics.
T. Kuriyama
,
T. Karasawa
,
K. Nakagawa
,
S. Nakamura
,
E. Yamamoto
Oral microbiology and immunology
2002
Corpus ID: 702159
In this study, we evaluated the current effectiveness of 11 beta-lactam antibiotics for treatment of orofacial odontogenic…
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2001
2001
Effect of experimental renal failure on the pharmacodynamics of cefoselis-induced seizures in rats.
M. Nagata
,
M. Yasuhara
Biological & pharmaceutical bulletin
2001
Corpus ID: 19710478
We investigated the effect of infusion rate and experimental renal failure on the pharmacodynamics of cefoselis (CFSL)-induced…
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Highly Cited
2000
Highly Cited
2000
β-Lactam Antibiotics as Substrates for OCTN2, an Organic Cation/Carnitine Transporter*
M. E. Ganapathy
,
W. Huang
,
+5 authors
V. Ganapathy
The Journal of Biological Chemistry
2000
Corpus ID: 4653931
Therapeutic use of cephaloridine, a β-lactam antibiotic, in humans is associated with carnitine deficiency. A potential mechanism…
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2000
2000
Synthesis and structure-activity relationships of quaternary ammonium cephalosporins with 3-pyrazolylpyridinium derivatives.
K. Chang
,
S. Kim
,
G. Nam
,
J. Seo
,
J. Kim
,
D. Ha
Bioorganic & medicinal chemistry letters
2000
Corpus ID: 27414901
Review
1997
Review
1997
Cefpirome. A review of its antibacterial activity, pharmacokinetic properties and clinical efficacy in the treatment of severe nosocomial infections and febrile neutropenia.
L. Wiseman
,
H. Lamb
Drugs
1997
Corpus ID: 195692199
Cefpirome is an injectable extended-spectrum or 'fourth generation' cephalosporin. Its antibacterial activity encompasses many of…
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Highly Cited
1996
Highly Cited
1996
Quantitative correlation between susceptibility and OprJ production in NfxB mutants of Pseudomonas aeruginosa
N. Masuda
,
N. Gotoh
,
S. Ohya
,
T. Nishino
Antimicrobial agents and chemotherapy
1996
Corpus ID: 22808031
Various Pseudomonas aeruginosa PAO1 NfxB mutants were isolated on agar plates containing cefpirome and ofloxacin. They were…
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