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National Institutes of Health
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Identifying Functional Hotspot Residues for Biased Ligand Design in G-Protein-Coupled Receptors
C. S. Tautermann
Corpus ID: 4735803
G-protein-coupled receptors (GPCRs) mediate multiple signaling pathways in the cell, depending on the agonist that activates the…
PROCESS FOR PREPARING ISOMERS OF CARMOTEROL CROSS-REFERENCE TO RELATED APPLICATIONS
Corpus ID: 55520652
Kobayashi, Yukio, et al., Database CA Online, Chemical Abstracts Service, 1993, 2 pages, Columbus, OH, XP 002480770. Foreign…
Structure-based fragment screening is demonstrated to be a practical lead discovery method for a representative G-protein-coupled receptor.
Benjamin D. Stevens
Journal of medicinal chemistry
Corpus ID: 207231722
F lead discovery efforts have made considerable impact on modern drug discovery programs over recent years. While less than a…
The reassertion profiles of long acting β2-adrenoceptor agonists in the guinea pig isolated trachea and human recombinant β2-adrenoceptor.
Pulmonary pharmacology & therapeutics
Corpus ID: 1235313
Long acting β(2)-adrenoceptor agonists as exemplified by salmeterol and formoterol, exhibit reassertion behaviour in isolated…
G protein-coupled receptors: Crystallizing how agonists bind
Man Tsuey Tse
Nature Reviews Drug Discovery
Corpus ID: 30984644
Our understanding of how agonists bind to and activate members of the superfamily of G protein-coupled receptors (GPCRs) has been…
Pharmacokinetic and Pharmacodynamic Interaction of Carmoterol and Budesonide in Asthmatic Patients.
Corpus ID: 75513349
The pharmacokinetic (PK) and pharmacodynamic (PD) interaction between budesonide (BUD), a well established inhaled corticosteroid…
Method of preparing an isomer of carmoterol
Corpus ID: 102564672
A process for preparing a compound of formula (III) comprising condensing an oxiranyl compound of formula (I) with an amine of…
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