canalicular bile acid transport

Catalysis of the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes… (More)
National Institutes of Health

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2001
2001
New horizons in the regulation of bile acid and lipid homeostasis: critical role of the nuclear receptor FXR as an intracellular bile acid sensor.
Bile acids (BA) play an important role in human physiology.1 As amphipathic water soluble end products of cholesterol metabolism… (More)
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Highly Cited
2000
Highly Cited
2000
Targeted Disruption of the Nuclear Receptor FXR/BAR Impairs Bile Acid and Lipid Homeostasis
Mice lacking the nuclear bile acid receptor FXR/BAR developed normally and were outwardly identical to wild-type littermates. FXR… (More)
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Review
1997
Review
1997
Bile acid transport across the hepatocyte canalicular membrane.
Transport of bile acids across the canalicular membrane of the hepatocyte provides the primary motive force for generation of… (More)
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1995
1995
Differential ontogenic regulation of basolateral and canalicular bile acid transport proteins in rat liver.
The hepatic transport systems mediating bile acid uptake and excretion undergo independent, stage-specific expression during… (More)
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1994
1994
Bile acid transport by the rat liver canalicular bile acid transport/ecto-ATPase protein is dependent on ATP but not on its own ecto-ATPase activity.
We have shown that bile acid efflux and ecto-ATPase activities are two distinct properties of a single rat liver hepatocyte… (More)
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1994
1994
Bile acid efflux mediated by the rat liver canalicular bile acid transport/ecto-ATPase protein requires serine 503 phosphorylation and is regulated by tyrosine 488 phosphorylation.
Transfection of cDNA for a hepatocyte canalicular phosphoprotein, the rat liver canalicular bile acid transporter/ecto-ATPase… (More)
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1993
1993
The rat liver ecto-ATPase is also a canalicular bile acid transport protein.
A approximately 110-kDa glycoprotein purified from canalicular vesicles by bile acid affinity chromatography has been identified… (More)
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1992
1992
ATP-dependent canalicular bile acid transport: another piece of the puzzle.
The secretion of bile by the liver is primarily determined by the ability of the hepatocyte to transport bile acids into the bile… (More)
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1991
1991
Postnatal expression of the canalicular bile acid transport system of rat liver.
Canalicular plasma membrane (CPM) vesicles prepared by a Ca2+ precipitation method from developing (7 and 14 days old) and adult… (More)
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1987
1987
Properties of the canalicular bile acid transport system in rat liver.
4,4-Di-isothiocyanostilbene-2,2'-disulphonic acid inhibition of taurocholate efflux from canalicular vesicles was used to… (More)
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