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camonagrel

Known as: 5-(2-imidazol-1-ylethoxy)-1-indancarboxylic acid 
 
National Institutes of Health

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Papers overview

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2010
2010
Pharmacokinetics of Camonagrel in experimental animal: rat, rabbit and dog
Camonagrel is a novel selective thromboxane synthetase inhibitor. The aim of this study was to determine its main pharmacokinetic… Expand
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2003
2003
Effects of Camonagrel, a Selective Inhibitor of Platelet Thromboxane Synthase, on the Platelet-Subendothelium Interaction
The aim of this study was to compare the effects of a new thromboxane synthase inhibitor, camonagrel, on platelet aggregation and… Expand
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2002
2002
Hypoxic pulmonary vasoconstriction in isolated blood-perfused rat lung; modulation by thromboxane A2, platelet-activating factor, cysteinyl leukotrienes and endothelin-1.
Recent evidence suggests that hypoxic pulmonary vasoconstriction (HPV) is mediated by hypoxia-induced closure of voltage-gated… Expand
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1999
1999
Biphasic response to lipopolysaccharide from E. coli in the isolated ventilated blood-perfused rat lung.
We characterised early circulatory and respiratory responses to lipopolysaccharide from E. coli (LPS, serotype 0127:B8) in the… Expand
1999
1999
Role of thromboxane A2 and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats.
The mechanism of early pulmonary and systemic haemodynamic response to intravenous infusion of LPS from Escherichia coli was… Expand
1998
1998
Effect of camonagrel, a selective thromboxane synthase inhibitor, on retinal vascularization in experimental diabetes.
Platelet hyperactivity accompanied by an increased synthesis of thromboxane and/or a decreased prostacyclin production are… Expand
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1998
1998
Protective role of pulmonary nitric oxide in the acute phase of endotoxemia in rats.
We present for the first time direct continuous assay of NO concentration (porphyrinic sensor) in the lung parenchyma of Sprague… Expand
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1996
1996
The effect of prostacyclin and nitric oxide on deformability of red blood cells in septic shock in rats.
Six hours after administration of E. Coli endotoxin (LPS) into rats (10 mg kg-1, i.p.) a significant (P < 0.001) decline in the… Expand
1996
1996
A paradox of thrombogenesis by streptokinase and its prevention by iloprost and camonagrel.
Here we report that streptokinase is responsible for forming thrombi both in vitro on blood-superfused endothelial cells of… Expand
1995
1995
The mechanism of anti-thrombotic, thrombolytic and fibrinolytic actions of camonagrel--a new thromboxane synthase inhibitor.
So far pharmacological consequences of inhibition of thromboxane A2 (TXA2) synthase by imidazole derivatives (e.g., camonagrel or… Expand
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