calyculin C
National Institutes of Health
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An asymmetric synthesis of the C(9)-C(25) spiroketal fragment of calyculin C is described. Key steps include two crotylation…
Calyculin C and Amphotericin B are biologically active natural products. Amphotericin B is an antifungal agent, which has been a…
Hypoxia induces bronchodilation in vivo and in vitro, but the mechanisms are still unclear. To evaluate whether an extra- or…
The synthesis of the C(26)-C(32) oxazole fragment 4 and its C(32) epimer 20 of serine/threonine protein phosphatase PP1 and PP2A…
We report our synthesis of the C(26)-C(37) fragment of serine/threonine protein phosphatase PP1 and PP2A inhibitor calyculin C (1…
Exposure of 3T3 fibroblasts to the phosphatase inhibitor, calyculin-A, induces marked morphological changes and the formation of…