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bromohydrin pyrophosphate

National Institutes of Health

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Diphosphates

Papers overview

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Review
2014
Review
2014
γδ T Cell-Mediated Immune Responses in Disease and Therapy
The role of γδ T cells in immunotherapy has gained specific importance in the recent years because of their prominent function… 
2012
2012
Synthesis of phosphoantigens: scalable accesses to enantiomers of BrHPP and studies on N-HDMAPP synthesis.
Highly Cited
2011
Highly Cited
2011
Expansion of human peripheral blood γδ T cells using zoledronate.
Human γδ T cells can recognize and respond to a wide variety of stress-induced antigens, thereby developing innate broad anti… 
Highly Cited
2009
Highly Cited
2009
Highly Active Microbial Phosphoantigen Induces Rapid yet Sustained MEK/Erk- and PI-3K/Akt-Mediated Signal Transduction in Anti-Tumor Human γδ T-Cells
Background The unique responsiveness of Vγ9Vδ2 T-cells, the major γδ subset of human peripheral blood, to non-peptidic prenyl… 
2007
2007
Large scale expansion of gamma 9 delta 2 T lymphocytes: Innacell gamma delta cell therapy product.
gamma9delta2 T lymphocytes are non-conventional lymphocytes presenting a direct cytotoxic effect against a broad range of tumour… 
Highly Cited
2005
Highly Cited
2005
In vivo immunomanipulation of V gamma 9V delta 2 T cells with a synthetic phosphoantigen in a preclinical nonhuman primate model.
Vgamma9Vdelta2(+) cells represent the major population of gammadelta T cells in primate blood and react in an MHC-unrestricted… 
Review
2005
Review
2005
Peripheral γδ T-lymphocytes as an innovative tool in immunotherapy for metastatic renal cell carcinoma
Renal cell carcinoma represents 3% of solid malignancies in adults and nephrectomy remains the main treatment. Failure of… 
Highly Cited
2002
Highly Cited
2002
Human gamma delta T cells induce dendritic cell maturation.
gamma delta T cells are known to be involved in the innate immune defenses against infectious microorganisms. Herein, we… 
2002
2002
Phosphoantigen presentation by macrophages to mycobacterium tuberculosis--reactive Vgamma9Vdelta2+ T cells: modulation by chloroquine.
Vgamma9Vdelta2+ T cells (gammadelta T cells) are activated by Mycobacterium tuberculosis and recognize mycobacterial nonpeptide… 
Highly Cited
2001
Highly Cited
2001
Chemical Synthesis and Biological Activity of Bromohydrin Pyrophosphate, a Potent Stimulator of Human γδ T Cells*
Small phosphorylated metabolites from mycobacteria stimulate human γδ T lymphocytes. Although such phosphoantigens could prove… 
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