brevican

Known as: Brain-Enriched Hyaluronan-Binding Protein, Chondroitin Sulfate Proteoglycan 7, Brain Enriched Hyaluronan Binding Protein 
A BRAIN-specific hyalectin that may play a role in terminally differentiating NEURONS. It is found highly overexpressed in primary BRAIN TUMORS and… (More)
National Institutes of Health

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BCAN geneIn BloodProcess of secretionagonists
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BCAN protein, human

Papers overview

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2009
2009
Brevican distinctively assembles extracellular components at the large diameter nodes of Ranvier in the CNS.
Brevican is known to be an abundant extracellular matrix component in the adult brain and a structural constituent of… (More)
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2008
2008
The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility.
The adult neural parenchyma contains a distinctive extracellular matrix that acts as a barrier to cell and neurite motility… (More)
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2005
2005
Human glioblastomas overexpress ADAMTS-5 that degrades brevican
Selective cleavage of the Glu395-Ser396 bond of brevican, one of the major proteoglycans in adult brain tissues, is thought to be… (More)
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Highly Cited
2003
Highly Cited
2003
The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury
Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that are widely expressed throughout the… (More)
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Highly Cited
2002
Highly Cited
2002
Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory.
Brevican is a brain-specific proteoglycan which is found in specialized extracellular matrix structures called perineuronal nets… (More)
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2002
2002
Brevican isoforms associate with neural membranes.
Brevican is a neural-specific proteoglycan of the brain extracellular matrix, which is particularly abundant in the terminally… (More)
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Highly Cited
2000
Highly Cited
2000
Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites.
Brevican is a member of the lectican family of chondroitin sulfate proteoglycans that is predominantly expressed in the central… (More)
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Highly Cited
1997
Highly Cited
1997
The brain chondroitin sulfate proteoglycan brevican associates with astrocytes ensheathing cerebellar glomeruli and inhibits neurite outgrowth from granule neurons.
Brevican is a nervous system-specific chondroitin sulfate proteoglycan that belongs to the aggrecan family and is one of the most… (More)
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Review
1996
Review
1996
Brevican: a major proteoglycan in adult brain.
A diverse set of proteoglycans is expressed in the developing and adult brain. This is in stark contrast to the fact that most… (More)
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Highly Cited
1994
Highly Cited
1994
Molecular cloning of brevican, a novel brain proteoglycan of the aggrecan/versican family.
To clone novel brain proteoglycans, we employed a strategy based on polyclonal antisera that recognize multiple proteoglycan core… (More)
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