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brevican

Known as: Brain-Enriched Hyaluronan-Binding Protein, Chondroitin Sulfate Proteoglycan 7, Brain Enriched Hyaluronan Binding Protein 
A BRAIN-specific hyalectin that may play a role in terminally differentiating NEURONS. It is found highly overexpressed in primary BRAIN TUMORS and… Expand
National Institutes of Health

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BCAN geneIn BloodProcess of secretionagonists
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BCAN protein, human

Papers overview

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Highly Cited
2012
Highly Cited
2012
The role of brevican in glioma: promoting tumor cell motility in vitro and in vivo
BackgroundMalignant glioma is a common primary tumor of the central nervous system. Brevican, an abundant extracellular matrix… Expand
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2007
2007
Discordant localization of WFA reactivity and brevican/ADAMTS-derived fragment in rodent brain
BackgroundProteoglycan (PG) in the extracellular matrix (ECM) of the central nervous system (CNS) may act as a barrier for… Expand
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Highly Cited
2005
Highly Cited
2005
Human glioblastomas overexpress ADAMTS-5 that degrades brevican
Selective cleavage of the Glu395-Ser396 bond of brevican, one of the major proteoglycans in adult brain tissues, is thought to be… Expand
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Highly Cited
2003
Highly Cited
2003
The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury
Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that are widely expressed throughout the… Expand
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Highly Cited
2002
Highly Cited
2002
Brevican-Deficient Mice Display Impaired Hippocampal CA1 Long-Term Potentiation but Show No Obvious Deficits in Learning and Memory
ABSTRACT Brevican is a brain-specific proteoglycan which is found in specialized extracellular matrix structures called… Expand
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Highly Cited
2000
Highly Cited
2000
Brain-enriched Hyaluronan Binding (BEHAB)/Brevican Cleavage in a Glioma Cell Line Is Mediated by a Disintegrin and Metalloproteinase with Thrombospondin Motifs (ADAMTS) Family Member*
Brain-enriched hyaluronan binding (BEHAB)/brevican is a brain-specific extracellular matrix protein containing a cleavage site… Expand
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Highly Cited
1998
Highly Cited
1998
Differential regulation of expression of hyaluronan-binding proteoglycans in developing brain: aggrecan, versican, neurocan, and brevican.
We have used a slot-blot radioimmunoassay to quantitate the levels of hyaluronan-binding chondroitin sulfate proteoglycans in… Expand
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Highly Cited
1997
Highly Cited
1997
The Brain Chondroitin Sulfate Proteoglycan Brevican Associates with Astrocytes Ensheathing Cerebellar Glomeruli and Inhibits Neurite Outgrowth from Granule Neurons
Brevican is a nervous system-specific chondroitin sulfate proteoglycan that belongs to the aggrecan family and is one of the most… Expand
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Highly Cited
1995
Highly Cited
1995
Brevican, a Chondroitin Sulfate Proteoglycan of Rat Brain, Occurs as Secreted and Cell Surface Glycosylphosphatidylinositol-anchored Isoforms (*)
cDNA clones encoding proteins related to the aggrecan/versican family of proteoglycan core proteins have been isolated with… Expand
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Highly Cited
1994
Highly Cited
1994
Molecular cloning of brevican, a novel brain proteoglycan of the aggrecan/versican family.
To clone novel brain proteoglycans, we employed a strategy based on polyclonal antisera that recognize multiple proteoglycan core… Expand
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