bouvardin
National Institutes of Health
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Protein synthesis is essential for growth, proliferation and survival of cells. Translation factors are overexpressed in many…
SUMMARY We described previously a screening protocol in Drosophila melanogaster that allows us to identify small molecules that…
The fast atom bombardment (FAB) mass spectra of bouvardin (1) 6-O-methylbouvardin (2), deoxybouvardin (3) and a synthetic analog…
Sarcoma-180 tumour (S-180) exhibits natural resistance to bouvardin (NSC 259968), a protein synthesis inhibitor that also…
A comparative study of cytostatic combinations was carried out in early and advanced murine leukaemia P388 by using the new…
Sarcoma-180 (S-180) tumor cells grown in Swiss mice displayed natural resistance to Bouvardin (NSC 259968) when administered…
The induction of complete resistance to adriamycin in L1210 leukemia was accomplished after 10 transplant generations. The…
The plant product Bouvardin (BVD; NSC 259968) exhibited high activity against P388 murine leukemia and B16 melanoma, but it was…
A subline of P388 leukemia resistant to adriamycin (P388/ADR) was developed by exposure to the drug in vivo. Resistance to…
Abstract Bouvardin (NSC 259968) was examined for effects on survival and cell cycle progression capacity in exponentially growing…